NDLI: A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population.

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A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qin, Ling Sun, Lin Ye, Lin Shi, Jieping Zhou, Liting Yang, Jingyu Du, Bing Song, Zikai Yu, Yaqin Xie, Lin
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Qin L ( Department of Cardiology, First Hospital, Jilin University, Changchun 130031, China.)
Abstract	To investigate the association between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2) and elongation of very long chain fatty acids like 2 (ELOVL2) gene and coronary artery disease (CAD) in a Chinese Han population. Three single nucleotide polymorphisms (SNPs) from these genes were genotyped using PCR-based restriction fragment length polymorphism analysis in 199 CAD cases and 192 controls of Han Chinese origin. rs174556 in the FADS1 gene showed allelic (P=0.002) and genotypic (P=0.030) association with the disease, while there was no disease association for the other two SNPs. The frequency of rs174556 minor allele (T) was significantly higher in the case group than the control group. The trans phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was weakly associated with the disease (P=0.043). rs174556 in the FADS1 gene is very likely to be associated with CAD in the Chinese Han population.
File Format	HTM / HTML
ISSN	09523278
Issue Number	6
Volume Number	85
e-ISSN	15322823
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Language	English
Publisher	Elsevier
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Acetyltransferases Genetics Asian Continental Ancestry Group Coronary Artery Disease Fatty Acid Desaturases Polymorphism, Single Nucleotide Adult Aged Aged, 80 And Over Case-control Studies China Enzymology Epistasis, Genetic Fatty Acids, Unsaturated Metabolism Female Gene Frequency Genetic Association Studies Haplotypes Humans Male Middle Aged Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Case study
Subject	Cell Biology Clinical Biochemistry

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