NDLI: A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study.

Please wait, while we are loading the content...

Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese-a 4- and 13-year descriptive epidemiologic study.

Dietary n-3/long-chain n-3 polyunsaturated fatty acids for prevention of sporadic colorectal tumors: a randomized controlled trial in polypectomized participants.

Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells.

Effects of Lipoxin A4 on antimicrobial actions of neutrophils in sepsis.

Comparison of docosahexaenoic acid uptake in murine cardiomyocyte culture and tissue: significance to physiologically relevant studies.

Reduced ex vivo stimulated IL-6 response in infants randomized to fish oil from 9 to 18 months, especially among PPARG2 and COX2 wild types.

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study.

Rho-kinase regulates human platelet activation induced by thromboxane A2 independently of p38 MAP kinase.

Docosahexaenoic acid (DHA) supplementation in pregnancy differentially modulates arachidonic acid and DHA status across FADS genotypes in pregnancy.

Prostaglandin E2 impairs osteogenic and facilitates adipogenic differentiation of human bone marrow stromal cells.

Dietary flax oil rich in -linolenic acid reduces renal disease and oxylipin abnormalities, including formation of docosahexaenoic acid derived oxylipins in the CD1-pcy/pcy mouse model of nephronophthisis.

The development of an ELISA for group IVA phospholipase A2 in human red blood cells.

Year: 2015 Volume: 93

Year: 2015 Volume: 92

Year: 2015 Volume: 102-103

Year: 2014 Volume: 91

Year: 2014 Volume: 90

Year: 2013 Volume: 89

Year: 2013 Volume: 88

Year: 2012 Volume: 87

Year: 2012 Volume: 86

Year: 2011 Volume: 85

Year: 2011 Volume: 84

Year: 2010 Volume: 83

Year: 2010 Volume: 82

Year: 2009 Volume: 81

Year: 2009 Volume: 80

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tintle, N. L. Pottala, J. V. Lacey, S. Ramachandran, V. Westra, J. Rogers, A. Clark, J. Olthoff, B. Larson, M. Harris, W. Shearer, G. C.
Spatial Coverage	Massachusetts
Description	Author Affiliation: Tintle NL ( Department of Mathematics, Statistics and Computer Science, Dordt College, Sioux Center, IA 51250, USA. Electronic address: nathan.tintle@dordt.edu.); Pottala JV ( Health Diagnostic Laboratory, Richmond, VA, USA); Lacey S ( Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave., Boston, MA, USA.); Ramachandran V ( Framingham Heart Study, 73 Mt. Wayte Ave., Framingham, MA 01702, USA); Westra J ( Department of Mathematics, Statistics and Computer Science, Dordt College, Sioux Center, IA 51250, USA.); Rogers A ( Department of Mathematics, Statistics and Computer Science, Dordt College, Sioux Center, IA 51250, USA.); Clark J ( Department of Mathematics, Statistics and Computer Science, Dordt College, Sioux Center, IA 51250, USA.); Olthoff B ( Department of Mathematics, Statistics and Computer Science, Dordt College, Sioux Center, IA 51250, USA.); Larson M ( Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave., Boston, MA, USA); Harris W ( Health Diagnostic Laboratory, Richmond, VA, USA); Shearer GC ( Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.)
Abstract	Most genome-wide association studies have explored relationships between genetic variants and plasma phospholipid fatty acid proportions, but few have examined apparent genetic influences on the membrane fatty acid profile of red blood cells (RBC). Using RBC fatty acid data from the Framingham Offspring Study, we analyzed over 2.5 million single nucleotide polymorphisms (SNPs) for association with 14 RBC fatty acids identifying 191 different SNPs associated with at least 1 fatty acid. Significant associations (p<1×10(-8)) were located within five distinct 1MB regions. Of particular interest were novel associations between (1) arachidonic acid and PCOLCE2 (regulates apoA-I maturation and modulates apoA-I levels), and (2) oleic and linoleic acid and LPCAT3 (mediates the transfer of fatty acids between glycerolipids). We also replicated previously identified strong associations between SNPs in the FADS (chromosome 11) and ELOVL (chromosome 6) regions. Multiple SNPs explained 8-14% of the variation in 3 high abundance (>11%) fatty acids, but only 1-3% in 4 low abundance (<3%) fatty acids, with the notable exception of dihomo-gamma linolenic acid with 53% of variance explained by SNPs. Further studies are needed to determine the extent to which variations in these genes influence tissue fatty acid content and pathways modulated by fatty acids.
File Format	HTM / HTML
ISSN	09523278
e-ISSN	15322823
DOI	10.1016/j.plefa.2014.11.007
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Volume Number	94
Language	English
Publisher	Elsevier
Publisher Date	2015-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Endocrinology Chromosomes, Human Genetics Erythrocytes Metabolism Fatty Acids Blood Genome-wide Association Study Polymorphism, Single Nucleotide 1-acylglycerophosphocholine O-acyltransferase Acetyltransferases Extracellular Matrix Proteins Genotype Glycoproteins Linkage Disequilibrium Longitudinal Studies Massachusetts Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Association between red blood cell fatty acids composition and risk of esophageal cancer: a hospital-based case-control study

Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.

Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.

Genetic loci associated with circulating levels of very long-chain saturated fatty acids.

Linkage-disequilibrium-based binning misleads the interpretation of genome-wide association studies.

A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population

Region-based analysis in genome-wide association study of Framingham Heart Study blood lipid phenotypes

Genome-wide association and genomic selection in animal breeding.

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study.

Similar Documents

Association between red blood cell fatty acids composition and risk of esophageal cancer: a hospital-based case-control study

Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.

Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.

Genetic loci associated with circulating levels of very long-chain saturated fatty acids.

Linkage-disequilibrium-based binning misleads the interpretation of genome-wide association studies.

A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population

Region-based analysis in genome-wide association study of Framingham Heart Study blood lipid phenotypes

Genome-wide association and genomic selection in animal breeding.

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study.