NDLI: Reduced ex vivo stimulated IL-6 response in infants randomized to fish oil from 9 to 18 months, especially among PPARG2 and COX2 wild types.

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Reduced ex vivo stimulated IL-6 response in infants randomized to fish oil from 9 to 18 months, especially among PPARG2 and COX2 wild types.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Harsløf, Laurine B. S. Damsgaard, Camilla T. Andersen, Anders D. Aakjær, Ditte L. Michaelsen, Kim F. Hellgren, Lars I. Frøkiær, Hanne Vogel, Ulla Lauritzen, Lotte
Description	Country affiliation: Denmark Author Affiliation: Harsløf LB ( Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.); Damsgaard CT ( Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.); Andersen AD ( Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.); Aakjær DL ( Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.); Michaelsen KF ( Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.); Hellgren LI ( Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.); Frøkiær H ( Department of Veterinary Disease Biology, Faculty of Health & Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.); Vogel U ( National Research Centre for the Working Environment, Copenhagen, Denmark.); Lauritzen L ( Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. Electronic address: ll@nexs.ku.dk.)
Abstract	We investigated whether n-3 LCPUFA affected immune function in late infancy and explored effect-modification by single nucleotide polymorphisms (SNPs) and links to intestinal microbiota. Infants (n=105) were randomized to fish oil (FO, 1.2g/d n-3 LCPUFA) or sunflower oil (SO)-supplements from age 9-18 months. Immune function was assessed by ex vivo cytokine production in stimulated blood and plasma immunoglobulin E (IgE). We genotyped functional SNPs in PPARG2 and COX2 and analyzed fecal microbiota by 16S-rRNA terminal restriction fragment length polymorphism. FO compared to SO reduced Lactobacillus paracasei-stimulated IL-6 at 18 months (P=0.03, n=104). This effect was most pronounced among infants wild-type for PPARG2-Pro12Ala and/or COX2-T8473C (P<0.05). Predominant bacterial fragments were associated with 18 months IgE in all infants (P=0.004) (bp100) and with IL-6 production among infants weaned before 9 months (P=0.047) (bp102). Thus, FO reduced IL-6 in a genotype-modified manner. The microbiota was partly linked to IL-6 and IgE, not directly to FO.
File Format	HTM / HTML
ISSN	09523278
Volume Number	94
e-ISSN	15322823
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Language	English
Publisher	Elsevier
Publisher Date	2015-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Cyclooxygenase 2 Genetics Fish Oils Administration & Dosage Interleukin-6 Metabolism Ppar Gamma Plant Oils Bacterial Infections Immunology Dietary Fats, Unsaturated Feces Microbiology Female Humans Immunoglobulin E Blood Infant Intestines Male Microbiota Drug Effects Polymorphism, Single Nucleotide Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Cell Biology Clinical Biochemistry

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