NDLI: Effect of acarbose on the increased plasma concentration of uric acid induced by sucrose ingestion.

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PP07: new approaches, new knowledge, new challenges in human purine and pyrimidine metabolism.

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Effect of acarbose on the increased plasma concentration of uric acid induced by sucrose ingestion.

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Effect of acarbose on the increased plasma concentration of uric acid induced by sucrose ingestion.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moriwaki, Y. Inokuchi, T. Ka, T. Yamamoto, A. Tsutsumi, Z. Takahashi, S. Yamamoto, T.
Description	Country affiliation: Japan Author Affiliation: Moriwaki Y ( Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. moriwaki@hyo-med.ac.jp)
Abstract	Sucrose is converted fructose and glucose, which may increase plasma uric acid concentration (pUA) through increased purine degradation and/or decreased uric acid (UA) excretion. To investigate effects of acarbose, an inhibitor of alpha-glucosidase, on the increased pUA from sucrose administration, we measured pUA and urinary UA excretion in 6 healthy subjects before and after administering sucrose, with and without co-administration of acarbose. Sucrose raised pUA by 10% (p < 0.01). However, excretion and fractional clearance of UA were unchanged. Sucrose and acarbose coadministration also increased pUA, but less than did sucrose alone (sucrose: 4.9 to 5.4 mg/dl; sucrose + acarbose, 4.7 to 4.9 mg/dl, p < 0.05) without changes in urinary excretion and fractional clearance of UA. Acarbose appears to attenuate the rise in pUA by sucrose ingestion by inhibiting sucrose absorption.
File Format	HTM / HTML
ISSN	15257770
Issue Number	6
Volume Number	27
e-ISSN	15322335
Journal	Nucleosides, Nucleotides and Nucleic Acids
Language	English
Publisher	Taylor & Francis
Publisher Date	2008-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Acarbose Pharmacology Enzyme Inhibitors Sucrose Uric Acid Blood Blood Glucose Metabolism Eating Glycoside Hydrolase Inhibitors Humans Insulin Lactic Acid Male Purines Administration & Dosage Clinical Trial Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Medicine

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