NDLI: Determinants of the clinical outcomes of gout during the first year of urate-lowering therapy.

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PP07: new approaches, new knowledge, new challenges in human purine and pyrimidine metabolism.

In memoriam: J. Edwin Seegmiller, M.D. (1920-2006).

In memoriam: Albert van Gennip (1943-2007).

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Molecular analysis of hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiencies: novel mutations and the spectrum of Japanese mutations.

Urinary guanidinoacetate and creatine levels in patients with HPRT deficiency.

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Determinants of the clinical outcomes of gout during the first year of urate-lowering therapy.

Asymptomatic hyperuricemia: impact of ultrasonography.

Production and characterization of transgenic mice harboring mutant human UMOD gene.

Effects of allopurinol on beer-induced increases in plasma concentrations of purine bases and uridine.

An unusual patient with hypothyroidism, tophaceous gout, and marked joint destruction.

Uric acid: the oxidant-antioxidant paradox.

Serum urate, metabolic syndrome, and cardiovascular risk factors. A population-based study.

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Purine contents of soybean-derived foods and selected Japanese vegetables and mushrooms.

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Application of metabolomic principles to disorders of nucleotide metabolism reveals new metabolic perturbations.

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Neurotrophic effects of extracellular guanosine.

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Guanine nucleotide depletion mediates translocation of nucleolar proteins, including RNA helicase A (DHX-9).

RNAi depletion of deoxycytidine and deoxyguanosine kinase in human leukemic CEM cells.

Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples.

Altered dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil containing chemotherapy.

Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.

Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells.

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Adenosine kinase gene expression in human colorectal cancer.

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Decreased ecto-NTPDase1/CD39 activity leads to desensitization of P2 purinoceptors regulating tonus of corpora cavernosa in impotent men with endothelial dysfunction.

Physiological and pharmacological roles of nucleoside transporter proteins.

Imatinib-resistant CML cells have low ENT activity but maintain sensitivity to gemcitabine.

Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples.

Degradation of pyrimidines in Saccharomyces kluyveri: transamination of beta-alanine.

Molecular mechanisms of mitochondrial DNA depletion diseases caused by deficiencies in enzymes in purine and pyrimidine metabolism.

Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria.

Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis.

Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis.

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Human cytidine triphosphate synthetase 1 interacting proteins.

5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts.

Cytoprotective effects of nicotinamide derivatives in endothelial cells.

Pharmacological inhibition of AMP-deaminase in rat cardiac myocytes.

A kinetic study of the rat liver adenosine kinase reverse reaction.

Modulation of AMP deaminase in rat hearts subjected to ischemia and reperfusion by purine riboside.

Mechanism of transition from xanthine dehydrogenase to xanthine oxidase: effect of guanidine-HCL or urea on the activity.

Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.

The role for glutamic acid at position 196 in human hypoxanthine phosphoribosyltransferase (HPRT) as investigated using site-directed mutagenesis.

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Determinants of the clinical outcomes of gout during the first year of urate-lowering therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Becker, Michael A. MacDonald, Patricia A. Hunt, Barbara J. Lademacher, Christopher Joseph-Ridge, Nancy
Description	Country affiliation: United States Author Affiliation: Becker MA ( Rheumatology Section, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA. mbecker@medicine.bsd.uchicago.edu)
Abstract	Clinical benefit early in urate-lowering treatment of gout is difficult to document. We examined data from 1,832 gouty subjects treated with either urate-lowering agents or placebo to identify determinants of gout flare incidence and tophus size during year 1 of treatment. Reductions from pretreatment serum urate levels influenced flare frequency and tophus size, but the effect of urate level on flare incidence was biphasic. Lower urate levels were associated with higher flare incidence early in treatment but lower incidence by one year. The complex relationship between urate-lowering and clinical outcome early in treatment has implications for both clinical and investigative approaches to urate-lowering management.
File Format	HTM / HTML
ISSN	15257770
Issue Number	6
Volume Number	27
e-ISSN	15322335
Journal	Nucleosides, Nucleotides and Nucleic Acids
Language	English
Publisher	Taylor & Francis
Publisher Date	2008-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Gout Suppressants Therapeutic Use Gout Therapy Allopurinol Febuxostat Drug Therapy Humans Linear Models Multivariate Analysis Odds Ratio Thiazoles Time Factors Treatment Outcome Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Medicine

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