NDLI: Efficacy of some antioxidants supplementation in reducing oxidative stress post sodium tungstate exposure in male wistar rats.

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Efficacy of some antioxidants supplementation in reducing oxidative stress post sodium tungstate exposure in male wistar rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sachdeva, S. Flora, S. J. S.
Description	Country affiliation: India Author Affiliation: Sachdeva S ( Division of Regulatory Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India.); Flora SJ ( Division of Regulatory Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India. Electronic address: sjsflora@drde.drdo.in.)
Abstract	This study aimed to evaluate the protective efficacy of some antioxidants against sodium tungstate induced oxidative stress in male wistar rats. Animals were sub-chronically exposed to sodium tungstate (100ppm in drinking water) for three months except for control group. In the same time, many rats were supplemented orally with different antioxidants (alpha-lipoic acid (ALA), n-acetylcysteine (NAC), quercetin or naringenin (0.30mM)) for five consecutive days a week for the same mentioned period before. Exposure to sodium tungstate significantly (P<0.05) inhibit blood Î´-aminolevulinic acid dehydratase (ALAD) activity, liver and blood reduced glutathione (GSH) levels and an increase in oxidized glutathione (GSSG) and thiobarbituric acid reactive species (TBARS) levels in tissues. ALA acid and NAC supplementation post sodium tungstate exposure increased GSH and also, was beneficial in the recovery of altered superoxide dismutase and catalase activity, besides, significantly reducing blood and tissue reactive oxygen species and TBARS levels. The results suggest a more pronounced efficacy of ALA acid and NAC supplementation than quercetin or naringenin supplementation post sodium tungstate exposure in preventing induced oxidative stress in rats.
File Format	HTM / HTML
ISSN	0946672X
Issue Number	2
Volume Number	28
e-ISSN	18783252
Journal	Journal of Trace Elements in Medicine and Biology
Language	English
Publisher	Elsevier
Publisher Date	2014-04-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Metabolism Discipline Environmental Health Antioxidants Pharmacology Dietary Supplements Oxidative Stress Drug Effects Tungsten Compounds Toxicity Animals Body Weight Liver Pathology Male Porphobilinogen Synthase Blood Rats, Wistar Spleen Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biochemistry Molecular Medicine Inorganic Chemistry

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