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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lashley, Lisa E. E. L. O. Haasnoot, Geert W. Spruyt-Gerritse, Marijke Claas, Frans H. J. |
| Description | Author Affiliation: Lashley LE ( Department of Gynecology and Obstetrics, Leiden University Medical Centre, the Netherlands. Electronic address: e.e.l.o.lashley@lumc.nl.); Haasnoot GW ( Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, the Netherlands.); Spruyt-Gerritse M ( Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, the Netherlands.); Claas FH ( Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, the Netherlands.) |
| Abstract | Oocyte donation (OD) enables women with various causes of reproductive failure to conceive, but is accompanied by a high risk of certain pregnancy disorders. Possibly, the allogeneic nature of the fetus in OD pregnancies plays a role in the development of these disorders. In this study, we investigated whether there is a selection for some degree of HLA matching in successful and uncomplicated OD pregnancies. Mothers and children from OD pregnancies that used unrelated donors (n=75) were typed for HLA-A, -B, -C, -DR, and -DQ and the observed number of HLA matches of the child was compared with the expected number of HLA matches. Moreover, we studied the possibility of a preferential selection for maternal KIR and fetal C combinations. We observed a significantly higher level of HLA matching between mother and child than expected by chance. In particular, the incidence of children with 5 or more HLA matches, which is the situation in autologous pregnancy, was higher than expected. A higher level of matching was shown, especially for HLA class I, while no significant differences were observed for the individual HLA loci. With respect to maternal KIR and fetal HLA-C no selection for a favorable combination was found. Larger observational studies including uncomplicated, preeclamptic, and aborted pregnancies are essential to determine to what extent HLA matching affects the outcome of OD pregnancies. |
| File Format | HTM / HTML |
| ISSN | 01650378 |
| Volume Number | 112 |
| e-ISSN | 18727603 |
| Journal | Journal of Reproductive Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Discipline Reproductive Medicine Abortion, Spontaneous Prevention & Control Donor Selection Methods Hla Antigens Immunology Histocompatibility Testing Oocyte Donation Pre-eclampsia Unrelated Donors Adult Female Humans Middle Aged Pregnancy Clinical Trial Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology Reproductive Medicine Obstetrics and Gynecology |
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