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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shiizaki, Kazuhiro Yoshikawa, Tomoya Takada, Eiji Hirose, Shizuma Ito-Harashima, Sayoko Kawanishi, Masanobu Yagi, Takashi |
| Description | Country affiliation: Japan Author Affiliation: Shiizaki K ( Department of Biology, Graduate School of Science, Osaka Prefecture University, Osaka, Japan.); Yoshikawa T ( Department of Biology, Graduate School of Science, Osaka Prefecture University, Osaka, Japan.); Takada E ( Department of Biology, Graduate School of Science, Osaka Prefecture University, Osaka, Japan.); Hirose S ( Department of Biology, Graduate School of Science, Osaka Prefecture University, Osaka, Japan.); Ito-Harashima S ( Department of Biology, Graduate School of Science, Osaka Prefecture University, Osaka, Japan.); Kawanishi M ( Department of Biology, Graduate School of Science, Osaka Prefecture University, Osaka, Japan.); Yagi T ( Department of Biology, Graduate School of Science, Osaka Prefecture University, Osaka, Japan) |
| Abstract | INTRODUCTION: Retinoic acids are essential for embryonic development, tissue organization, and homeostasis and act via retinoic acid receptors (RARs) that form heterodimers with retinoid X receptors (RXRs). Human RARs and RXRs include the three subtypes , ß, and γ, which have varying distributions and physiological functions among human tissues. Recent reports show that subtype-specific binding of several chemicals to RARs or RXRs may lead to endocrine disruption. To evaluate these ligand-like chemicals, convenient assay systems for each receptor subtype are required. METHODS: We developed reporter assay yeasts to screen ligands for RXR subtype receptor homodimers. To screen RAR ligands, yeasts were engineered to express RAR subtypes with defective RXR , which fails to bind to coactivators because of its shortened c-terminus. RESULTS: These assay yeasts were validated using known RXR- and RAR-specific ligands and subtype-specific responses were clearly shown. Subtype-specific ligand activities of the suspected chemical RAR or RXR ligands o-t-butylphenol, triphenyltin chloride, tributyltin chloride, and 4-nonylphenol were determined. DISCUSSION: The present assay yeasts may be valuable tools for subtype-specific assessments of unidentified environmental ligand chemicals and receptor-specific pharmaceuticals. |
| File Format | HTM / HTML |
| ISSN | 10568719 |
| Issue Number | 3 |
| Volume Number | 69 |
| e-ISSN | 1873488X |
| Journal | Journal of Pharmacological and Toxicological Methods |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Discipline Pharmacology Receptors, Retinoic Acid Metabolism Retinoid X Receptors Saccharomyces Cerevisiae Genetics Tretinoin Genes, Reporter Humans Ligands Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology Pharmacology |
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