NDLI: Local and systemic toxicity of Echis carinatus venom: neutralization by Cassia auriculata L. leaf methanol extract.

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Local and systemic toxicity of Echis carinatus venom: neutralization by Cassia auriculata L. leaf methanol extract.

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Local and systemic toxicity of Echis carinatus venom: neutralization by Cassia auriculata L. leaf methanol extract.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nanjaraj Urs, A. N. Yariswamy, M. Joshi, Vikram Suvilesh, K. N. Sumanth, M. S. Das, Diganta Nataraju, A. Vishwanath, B. S.
Description	Author Affiliation: Nanjaraj Urs AN ( Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India, 570 006.)
Abstract	Viper bites cause high morbidity and mortality especially in tropical and subtropical regions, affecting a large number of the rural population in these areas. Even though anti-venoms are available, in most cases they fail to tackle viper venom-induced local manifestations that persist even after anti-venom administration. Several studies have been reported the use of plant products and approved drugs along side anti-venom therapy for efficient management of local tissue damage. In this regard, the present study focuses on the protective efficacy of Cassia auriculata L. (Leguminosae) against Echis carinatus venom (ECV) induced toxicity. C. auriculata is a traditional medicinal plant, much valued in alternative medicine for its wide usage in ayurveda, naturopathy, and herbal therapy. Further, it has been used widely by traditional healers for treatment of snake and scorpion bites in the Western Ghats of Karnataka, India. In the present study, C. auriculata leaf methanol extract (CAME) significantly inhibited enzymatic activities of ECV proteases (96 ± 1 %; P = 0.001), PLA2 (45 ± 5 %; P = 0.01) and hyaluronidases (100 %; P = 0.0003) in vitro and hemorrhage, edema and myotoxicity in vivo. Further, CAME effectively reduced the lethal potency of ECV and increased the survival time of mice by ~6 times (17 vs 3 h). These inhibitory potentials of CAME towards hydrolytic enzymes, mortal and morbid symptoms of ECV toxins clearly substantiates the use by traditional healers of C. auriculata as a folk medicinal remedy for snakebite.
File Format	HTM / HTML
ISSN	13403443
Issue Number	1
Volume Number	69
e-ISSN	18610293
Journal	Journal of Natural Medicines
Language	English
Publisher	Springer
Publisher Date	2015-01-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Complementary Therapies Antivenins Therapeutic Use Cassia Chemistry Phytotherapy Viper Venoms Antagonists & Inhibitors Animals Blood Coagulation Factors Edema Chemically Induced Prevention & Control Hemorrhage Humans Hyaluronoglucosaminidase Male Methanol Mice Phenols Isolation & Purification Phytochemicals Plant Extracts Plant Leaves Toxicity Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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Local and systemic toxicity of Echis carinatus venom: neutralization by Cassia auriculata L. leaf methanol extract

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