NDLI: Risk factors and molecular analysis of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus colonization and infection in children.

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Risk factors and molecular analysis of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus colonization and infection in children.

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Risk factors and molecular analysis of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus colonization and infection in children.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chiu, Yaw-Kwan Lo, Wen-Tsung Wang, Chih-Chien
Description	Country affiliation: Taiwan Author Affiliation: Chiu YK ( Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.)
Abstract	BACKGROUND AND PURPOSE: Limited information is available regarding the role Panton-Valentine leukocidin (PVL) plays in methicillin-susceptible Staphylococcus aureus (MSSA). In this study, we compared the frequency of the PVL gene between MSSA strains isolated from patients with MSSA infections and MSSA strains isolated from patients with evidence of MSSA nasal colonization. We also explored the role that the PVL toxin plays in the ability of MSSA to cause disease as well as the phylogenetic relationship between these S aureus strains. METHODS: The presence of MSSA strains was screened among children aged <18 years during routine health maintenance visits and among children aged <7 years at daycare centers or kindergartens during the 2003 to 2008 period. At the same time, clinical MSSA isolates were recovered from patients with various types of bacterial infections. Polymerase chain reaction was applied to detect the presence of the PVL and SEB genes in these strains. The strains were also subjected to pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) studies. Clinical features were compared between patients with PVL-positive and those with PVL-negative isolates. RESULTS: A total of 495 colonizing MSSA and 71 clinical MSSA isolates were used. The prevalence of PVL-positive S aureus was significantly higher among clinical isolates than among colonizing isolates (14/71, 19.7%; 5/495, 1.0%; p < 0.05). In addition, we found that patients with PVL-positive MSSA infections had a significantly longer duration of fever and tended to have higher C-reactive protein levels than patients with PVL-negative MSSA infections. MLST typing of the 19 PVL-positive MSSA isolates revealed ST59, a strain that is similar to the MLST type of community-associated methicillin-resistant Staphylococcus aureus found in Taiwan. The PFGE typing of PVL-positive/ST59 MSSA isolates revealed multiple pulsotypes. CONCLUSION: The prevalence of the PVL gene was significantly higher among clinical strains of MSSA (19.7%) than among colonizing strains (1.0%). In addition, patients infected with PVL-positive MSSA strains had fever for a significantly longer duration and tended to have higher C-reactive protein levels than patients with PVL-negative MSSA infections. Our findings imply that PVL may play an important role in the pathogenesis of S aureus infection.
File Format	HTM / HTML
ISSN	16841182
e-ISSN	19959133
Journal	Journal of Microbiology, Immunology and Infection
Issue Number	3
Volume Number	45
Language	English
Publisher	Elsevier
Publisher Date	2012-06-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Microbiology Discipline Immunology Bacterial Toxins Genetics Exotoxins Leukocidins Methicillin-resistant Staphylococcus Aureus Staphylococcal Infections Microbiology Adolescent Child, Preschool Community-acquired Infections Electrophoresis, Gel, Pulsed-field Infant Infant, Newborn Classification Isolation & Purification Multilocus Sequence Typing Phylogeny Retrospective Studies Statistics, Nonparametric Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Microbiology Immunology and Allergy Microbiology (medical)

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