NDLI: Adult Brugia malayi mitochondrial and nuclear fractions impart Th1-associated sizeable protection against infective larval challenges in Mastomys coucha.

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Adult Brugia malayi mitochondrial and nuclear fractions impart Th1-associated sizeable protection against infective larval challenges in Mastomys coucha.

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Adult Brugia malayi mitochondrial and nuclear fractions impart Th1-associated sizeable protection against infective larval challenges in Mastomys coucha.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shakya, S. Srivastava, A. K. Misra-Bhattacharya, S.
Description	Country affiliation: India Author Affiliation: Shakya S ( Divisions of Parasitology, Central Drug Research Institute, M.G. Marg, Post Box 173, Lucknow 226001, Uttar Pradesh, India.)
Abstract	Protective immunity to the subperiodic human filariid, Brugia malayi, was explored in the rodent host, Mastomys coucha after vaccination with subcellular fractions derived from the adult stage of the parasite. The highest level of protection was conferred in animals vaccinated with the 'mitochondria rich' (MT) fraction, in which microfilaraemia and worm burden were markedly reduced by 67.2 and 65.9%, respectively, followed by the 'nucleus rich' (NR) fraction, showing reductions of 62 and 52.3%, respectively, over the non-immunized control group. Mastomys vaccinated with MT and NR, displayed a significant increase in the level of antigen-specific serum immunoglobulin G (IgG). The levels of IgG2a, IgG2b and IgM antibody isotypes were remarkably elevated in both the MT and NR immunized groups, while IgG1 and IgG3 levels were low. Apart from antibodies, both these fractions also led to marked antigen-specific lymphoproliferation in vitro, along with enhanced release of nitric oxide by peritoneal macrophages. There was an increased population of CD4+ and CD8a+T-cells in MT immunized animals, as measured by flow cytometry, accompanied by elevated levels of proinflammatory cytokines; interferon gamma (IFN-gamma), tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in the culture supernatants of the activated splenocytes. The results suggest that both NR and MT contain proinflammatory molecules which evoke a protective Th1 type of immune response.
File Format	HTM / HTML
ISSN	0022149X
Issue Number	1
Volume Number	83
e-ISSN	14752697
Journal	Journal of Helminthology
Language	English
Publisher	Cambridge University Press
Publisher Date	2009-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Parasitology Antigens, Helminth Immunology Brugia Malayi Elephantiasis, Filarial Subcellular Fractions Th1 Cells Animals Isolation & Purification Cell Fractionation Centrifugation Disease Models, Animal Blood Prevention & Control Humans Immunoglobulin G Larva Male Microfilaria Muridae Th2 Cells Vaccination Methods Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Parasitology Animal Science and Zoology

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