NDLI: A combination of two Brugia malayi filarial vaccine candidate antigens (BmALT-2 and BmVAH) enhances immune responses and protection in jirds.

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A combination of two Brugia malayi filarial vaccine candidate antigens (BmALT-2 and BmVAH) enhances immune responses and protection in jirds.

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A combination of two Brugia malayi filarial vaccine candidate antigens (BmALT-2 and BmVAH) enhances immune responses and protection in jirds.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Anand, S. B. Kodumudi, K. N. Reddy, M. V. Kaliraj, P.
Description	Country affiliation: India Author Affiliation: Anand SB ( Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai - 625021, India.)
Abstract	In this study filarial recombinant protein or DNA vaccine constructs encoding BmALT-2 and BmVAH as single or as cocktail antigens were evaluated. Male jirds were immunized intramuscularly with DNA vaccine constructs or were immunized intraperitoneally with protein vaccine. The single and bicistronic DNA constructs induced substantial interferon-Î³ responses in spleen cells; antigen-specific responses were higher following immunization with the bicistronic cocktail construct and evoked a significant protective response of 57% in jirds challenged with Brugia malayi that was similar in the antibody-dependent cellular cytotoxicity (ADCC) assay and micropore chamber experiment. The cocktail protein vaccines induced a mixture of IgG2a (Th1) and IgG1 (Th2) responses with 80% protective response when challenged with B. malayi infective larvae. However, the single protein vaccine rALT-2 induced Th2 (IgG1/IgG3) with a 70% protective response and rVAH induced Th1 (IgG2a) with a lower proliferative response with 60% protection following challenge with B. malayi infective larvae. These results suggest that filarial cocktail protein vaccines are able to elicit substantial immune and protective responses when compared with single antigen vaccination in suitably vaccinated jirds.
File Format	HTM / HTML
ISSN	0022149X
Issue Number	4
Volume Number	85
e-ISSN	14752697
Journal	Journal of Helminthology
Language	English
Publisher	Cambridge University Press
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Parasitology Antibodies, Helminth Blood Antigens, Helminth Immunology Brugia Malayi Elephantiasis, Filarial Prevention & Control Gerbillinae Recombinant Proteins Vaccines, Dna Animals Genetics Metabolism Pathogenicity Cho Cells Cricetinae Disease Models, Animal Immunization Immunoglobulin G Male Administration & Dosage Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Parasitology Animal Science and Zoology

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