NDLI: Urinary biomarker concentrations of captan, chlormequat, chlorpyrifos and cypermethrin in UK adults and children living near agricultural land.

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Urinary biomarker concentrations of captan, chlormequat, chlorpyrifos and cypermethrin in UK adults and children living near agricultural land.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Galea, Karen S. MacCalman, Laura Jones, Kate Cocker, John Teedon, Paul Cherrie, John W. Van Tongeren, Martie
Description	Country affiliation: United kingdom Author Affiliation: Galea KS ( Centre for Human Exposure Science, Institute of Occupational Medicine (IOM), Edinburgh, UK.); MacCalman L ( Centre for Human Exposure Science, Institute of Occupational Medicine (IOM), Edinburgh, UK.); Jones K ( Health and Safety Laboratory, Buxton, UK.); Cocker J ( Health and Safety Laboratory, Buxton, UK.); Teedon P ( School of Engineering and the Built Environment, Glasgow Caledonian University, Glasgow, UK.); Cherrie JW ( Centre for Human Exposure Science, Institute of Occupational Medicine (IOM), Edinburgh, UK.); van Tongeren M ( School of Life Sciences, Heriot Watt University, Edinburgh, UK.)
Abstract	There is limited information on the exposure to pesticides experienced by UK residents living near agricultural land. This study aimed to investigate their pesticide exposure in relation to spray events. Farmers treating crops with captan, chlormequat, chlorpyrifos or cypermethrin provided spray event information. Adults and children residing ≤100 m from sprayed fields provided first-morning void urine samples during and outwith the spray season. Selected samples (1-2 days after a spray event and at other times (background samples)) were analysed and creatinine adjusted. Generalised Linear Mixed Models were used to investigate if urinary biomarkers of these pesticides were elevated after spray events. The final data set for statistical analysis contained 1518 urine samples from 140 participants, consisting of 523 spray event and 995 background samples which were analysed for pesticide urinary biomarkers. For captan and cypermethrin, the proportion of values below the limit of detection was greater than 80%, with no difference between spray event and background samples. For chlormequat and chlorpyrifos, the geometric mean urinary biomarker concentrations following spray events were 15.4 µg/g creatinine and 2.5 µg/g creatinine, respectively, compared with 16.5 µg/g creatinine and 3.0 µg/g creatinine for background samples within the spraying season. Outwith the spraying season, concentrations for chlorpyrifos were the same as those within spraying season backgrounds, but for chlormequat, lower concentrations were observed outwith the spraying season (12.3 µg/g creatinine). Overall, we observed no evidence indicative of additional urinary pesticide biomarker excretion as a result of spray events, suggesting that sources other than local spraying are responsible for the relatively low urinary pesticide biomarkers detected in the study population.
File Format	HTM / HTML
ISSN	15590631
e-ISSN	1559064X
DOI	10.1038/jes.2015.54
Journal	Journal of Exposure Science and Environmental Epidemiology
Issue Number	6
Volume Number	25
Language	English
Publisher	Macmillan Publishers Limited
Publisher Date	2015-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Environmental Health Discipline Epidemiology Agriculture Statistics & Numerical Data Captan Urine Chlormequat Chlorpyrifos Environmental Exposure Pesticides Pyrethrins Adolescent Biological Markers Child, Preschool Questionnaires Epidemiology Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pollution Public Health, Environmental and Occupational Health Toxicology Epidemiology

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