NDLI: Bisphenol A exposure pathways in early childhood: Reviewing the need for improved risk assessment models.

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Bisphenol A exposure pathways in early childhood: Reviewing the need for improved risk assessment models.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Healy, Bridget F. English, Karin R. Jagals, Paul Sly, Peter D.
Description	Country affiliation: Australia Author Affiliation: Healy BF ( Children's Health and Environment Program, Queensland Children's Medical Research Institute, Brisbane, Queensland, Australia.); English KR ( School of Public Health, University of Queensland, Brisbane, Queensland, Australia.); Jagals P ( Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia.); Sly PD ( Children's Health and Environment Program, Queensland Children's Medical Research Institute, Brisbane, Queensland, Australia.)
Abstract	Bisphenol A (BPA) is a plasticiser found in a number of household plastics, electronics, and food-packaging materials. Over the past 5 years, several human epidemiological studies have reported a positive association between BPA exposure and adverse health outcomes in children, including obesity, asthma, preterm birth, and neuro-behavioural disturbances. These findings are in conflict with international environmental risk assessment models, which predict daily exposure levels to BPA should not pose a risk to child health. The aim of this review is to provide an overview of the evidence for different exposure sources and potential exposure pathways of BPA in early childhood. By collating the findings from experimental models and exposure associations observed in human bio-monitoring studies, we affirm the potential for non-dietary sources to make a substantial contribution to total daily exposure in young children. Infants and toddlers have distinctive exposure sources, physiology, and metabolism of endocrine-disrupting chemicals. We recommend risk-assessment models implement new frameworks, which specifically address exposure and hazard in early childhood. This is particularly important for BPA, which is present in numerous products in the home and day-care environments, and for which animal studies report contradictory findings on its safety at environmentally relevant levels of exposure.
File Format	HTM / HTML
ISSN	15590631
Issue Number	6
Volume Number	25
e-ISSN	1559064X
Journal	Journal of Exposure Science and Environmental Epidemiology
Language	English
Publisher	Macmillan Publishers Limited
Publisher Date	2015-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Epidemiology Benzhydryl Compounds Adverse Effects Environmental Exposure Phenols Child, Preschool Analysis Environmental Monitoring Humans Models, Theoretical Risk Assessment Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Pollution Public Health, Environmental and Occupational Health Toxicology Epidemiology

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