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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Raja, Mazhar Ali Arif, Muhammad Feng, Chao Zeenat, Shah Liu, Chen-Guang |
| Description | Author Affiliation: Raja MA ( College of Marine Life Sciences, Ocean University of China, Qingdao, PR China.); Arif M ( College of Marine Life Sciences, Ocean University of China, Qingdao, PR China.); Feng C ( College of Marine Life Sciences, Ocean University of China, Qingdao, PR China.); Zeenat S ( College of Marine Life Sciences, Ocean University of China, Qingdao, PR China.); Liu CG ( College of Marine Life Sciences, Ocean University of China, Qingdao, PR China.) |
| Abstract | A novel pH-responsive polymer based on amphiphilic N-acetyl histidine and arginine-grafted chitosan was synthesized using N-acetyl histidine as hydrophobic segment and arginine as hydrophilic segment by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide-mediated coupling reactions as anticancer drug delivery system for doxorubicin. The structure of the synthesized polymer was confirmed by Fourier transform infrared and H nuclear magnetic resonance analysis. Due to self-association behavior, N-acetyl histidine and arginine-grafted chitosan structured nanoparticles with in size range of 204 nm. N-acetyl histidine and arginine-grafted chitosan with different substitution degree of N-acetyl histidine were initially prepared and characterized. The critical micelle concentration decreased with increasing substitution degree of N-acetyl histidine. Furthermore, N-acetyl histidine and arginine-grafted chitosan nanoparticles exhibited an acidic pH-triggered aggregation and disassembling nature. The doxorubicin-encapsulated nanoparticles based on synthesized conjugate ( N-acetyl histidine and arginine-grafted chitosan/doxorubicin nanoparticles) showed a sustained drug release pattern, which could be hastened under acidic pH conditions but delayed with increasing substitution degree of N-acetyl histidine. Anticancer effects demonstrated that N-acetyl histidine and arginine-grafted chitosan/doxorubicin nanoparticles could suppress both sensitive and resistant human breast tumor cell line (MCF-7) efficiently in a dose- and time-dependent pattern. Confocal microscopy results evidenced increased cellular uptake and enhanced retention of the synthesized nanoparticles in drug-resistant cells demonstrating better efficacy of nanoparticles over native doxorubicin. These results suggest that N-acetyl histidine and arginine-grafted chitosan/doxorubicin nanoparticles might be promising carriers for delivery of hydrophobic drug doxorubicin against drug-resistant tumors. |
| File Format | HTM / HTML |
| ISSN | 08853282 |
| Issue Number | 8 |
| Journal | Journal of Biomaterials Applications |
| Volume Number | 31 |
| e-ISSN | 15308022 |
| Language | English |
| Publisher | Sage Publication |
| Publisher Date | 2017-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biomedical Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biomedical Engineering |
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