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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Jinwen Li, Weixuan Piao, Xiaoyu Zhang, Junwen Zhang, Dongzhi Wei, Ning Hu, Defu Liu, Shuqiang |
| Description | Author Affiliation: Liu J ( College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, People's Republic of China.) |
| Abstract | The present study demonstrates that Icariside II (10, 20, and 40 µM) reduced Leydig cell testosterone production and cell viability in a concentration- and time-dependent manner. Hoechst 33342/propidium iodide staining indicated that no morphological changes in Leydig cell nuclear chromatin occurred, caspase-3 expression also showed no significant change, but cell death was caused by the 10-µM Icariside II treatment. Furthermore, a significant reduction in NAD(+) levels was observed following Icariside II exposure (10, 20, and 40 µM). Cell death was avoided when Icariside II treated cells were incubated with extracellular NAD(+) (5 and 10 mM). Moreover, the addition of NAD(+) (5 and 10 mM) could restore ATP production and prevent cell death. The results suggest that Icariside II can reduce testosterone production by inducing necrosis, but not apoptosis, in rat Leydig cells. This mechanism may also account for the Icariside II induced depletion of NAD(+) and ATP levels. |
| File Format | HTM / HTML |
| ISSN | 10956670 |
| Issue Number | 4 |
| Volume Number | 27 |
| e-ISSN | 10990461 |
| Journal | Journal of Biochemical and Molecular Toxicology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2013-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Discipline Biochemistry Discipline Toxicology Flavonoids Toxicity Leydig Cells Drug Effects Pathology Testosterone Biosynthesis Adenosine Triphosphate Metabolism Animals Apoptosis Chorionic Gonadotropin Pharmacology Culture Media Chemistry Male Nad Necrosis Rats Rats, Sprague-dawley Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Molecular Biology Biochemistry Toxicology Molecular Medicine |
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