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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Svechnikov, Konstantin Svechnikova, Irina Söder, Olle |
| Description | Country affiliation: Sweden Author Affiliation: Svechnikov K ( Department of Woman and Child Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institute & University Hospital, SE-17176 Stockholm, Sweden. konstantin.svechnikov@ki.se) |
| Abstract | Di-2-ethylhexyl (DEHP) phthalate, one of the phthalates most widely distributed in our general environment, causes reproductive toxicity that is attributable to the action of its primary metabolite, mono(2-ethylhexyl) phthalate (MEHP). Here, we have investigated the effects of MEHP on steroidogenesis by primary cultures of immature and adult rat Leydig cells. In both cases MEHP (250muM) was found to inhibit stimulation of androgen production evoked by human chorionic gonadotropin (hCG). This was associated with decreased expression of steroidogenic acute regulatory (StAR) protein and reduced transport of cholesterol into mitochondria but no detectable adverse effect on steroidogenic enzymes. Moreover, upon exposure to MEHP alone, 5alpha-reductase activity was decreased in immature, but not in adult Leydig cells. All together, our findings demonstrate that MEHP exerts suppressive effects on hCG-activated steroidogenesis in primary cultures of immature and adult rat Leydig cells and suppresses 5alpha-reductase activity in immature and not of adult rat cells. This may partly explain the anti-androgenic effects of DEHP in vivo and indicate a higher susceptibility in younger subjects. |
| File Format | HTM / HTML |
| ISSN | 08906238 |
| Issue Number | 4 |
| Volume Number | 25 |
| e-ISSN | 18731708 |
| Journal | Reproductive Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-08-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Embryology Discipline Reproductive Medicine Discipline Toxicology Diethylhexyl Phthalate Analogs & Derivatives Leydig Cells Drug Effects Plasticizers Toxicity 3-oxo-5-alpha-steroid 4-dehydrogenase Metabolism Androstane-3,17-diol Animals Cells, Cultured Cholesterol Chorionic Gonadotropin Pharmacology Male Phosphoproteins Rats Rats, Sprague-dawley Testosterone Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology |
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