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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Attia, Sabry M. Harisa, Gamaleldin I. Abd-Allah, Adel R. Ahmad, Sheikh Fayaz Bakheet, Saleh A. |
| Description | Author Affiliation: Attia SM ( Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia. attiasm@ksu.edu.sa) |
| Abstract | The ability of the flavonoid lentinan (LAN) to enhance the repair of paclitaxel (PAC)-induced DNA damage and apoptosis in mouse bone marrow cells was investigated. Moreover, the possible mechanism underlying this modulation was determined. LAN was neither genotoxic nor apoptogenic at doses equivalent to 1 or 2 mg/kg/day. Pretreatment of mice with LAN significantly enhances the repair of PAC-induced DNA damage and bone marrow suppression in a dose dependent manner. Moreover, LAN affords significant protection against PAC-induced apoptosis. A significant increase of reactive oxygen species and a decrease in reduced glutathione levels were observed after PAC treatment and prior administration of LAN before PAC challenge ameliorated these oxidative stress markers. Conclusively, our study provides, for the first time, that LAN enhances the repair of PAC-induced DNA damage and apoptosis that resides, at least in part, on its ability to modulate the cellular antioxidant levels and consequently protect bone marrow cells from PAC genotoxicity. |
| File Format | HTM / HTML |
| ISSN | 10956670 |
| Issue Number | 7 |
| Volume Number | 27 |
| e-ISSN | 10990461 |
| Journal | Journal of Biochemical and Molecular Toxicology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Discipline Biochemistry Discipline Toxicology Adjuvants, Immunologic Pharmacology Antineoplastic Agents, Phytogenic Adverse Effects Apoptosis Drug Effects Bone Marrow Cells Metabolism Dna Damage Dna Repair Lentinan Paclitaxel Animals Pathology Cells, Cultured Male Mice Reactive Oxygen Species Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Molecular Biology Biochemistry Toxicology Molecular Medicine |
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