NDLI: Characterization of Endoplasmic Reticulum Stress and Apoptosis in Macrophages Infected with Mycobacterium tuberculosis Isolates from Korea Patients

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Jung Hwan Lim, Yun Ji Choi, Ji Ae Han, Ji Ye Cho, Sung Hee Oh, Sung Man Song, Chang Hwa
Spatial Coverage	KOREA
Description	Responsible library: WPRO
Abstract	Apoptosis is an important host defense mechanism against mycobacterial infection. Recent reports suggest that links between apoptosis and endoplasmic reticulum (ER) stress are critical for the regulation of mycobacterial survival; however, the exact regulatory mechanisms are not well known. In this study, we isolated 20 Mycobacterium tuberculosis (Mtb) clinical strains from Korean patients and examined ER stress-mediated apoptosis in Mtb-infected macrophages. Most Mtb strains increased the rates of apoptosis and production of ER stress-sensing molecules in mouse macrophages, similar to Mtb H37Rv infection. Moreover, the intracellular survival of Mtb clinical isolates in macrophages was similar to that of H37Rv. Our data suggest that infection with Mtb downregulated MCP-1 and MCPIP. The regulation of MCPIP may decrease ROS production, leading to a reduction in ER stress-mediated apoptosis.
File Format	HTM / HTML
ISSN	15982467
e-ISSN	20930429
Journal	Journal of Bacteriology and Virology
Issue Number	3
Volume Number	45
Language	Korean
Publisher	Korean Society for Microbiology Korean Society of Virology
Publisher Date	2015-01-01
Publisher Place	Korea (South)
Access Restriction	Open
Subject Keyword	Discipline Microbiology Discipline Virology Discipline Infectious Diseases Discipline Bacteriology Animals Apoptosis Endoplasmic Reticulum Stress Endoplasmic Reticulum Korea Macrophages Mice Mycobacterium Tuberculosis Mycobacterium Original Article
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology

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