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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jeong, Jin Ju Lee, Yong Sup Kim, Dong Hyun |
| Description | Responsible library: WPRO |
| Abstract | In the previous study, we found that flavonoids and ginsenosides exhibited high eliminate rates of human immunodeficiency virus type 1 (HIV-1) D3-transfected macrophages. Based on these findings, here we synthesized the derivatives of gallic acid, including methyl gallate, methyl 4-O-methyl gallate, methyl 3,4-O-dimethyl gallate, and methyl 3,4,5-O-trimethyl gallate and measured their cellular toxic effects against HIV-1-infected macrophages. Of these, treatment with methyl 4-O-methyl gallate in the presence of lipopolysaccharide (LPS) and cycloheximide (CHX) most effectively eliminated HIV-1-transfected cytoprotective human microglial CHME5 cells and HIV-1-D3-infected human primary macrophages. Furthermore, these strongly inhibited LPS/CHX-induced phosphorylation of phosphoinositide 3-kinase (PI3K), pyruvate dehydrogenase lipoamide kinase isozyme 1 (PDK1), Akt, and glycogen synthase kinase-3β (GSK-3β) in the Tat-transfected cells and HIV-1-D3-infected human primary macrophages. These findings suggest that methyl 4-O-methyl gallate may be a promising candidate for eliminating HIV-1 infected macrophages by blocking PI3K/Akt signaling pathway. |
| File Format | HTM / HTML |
| ISSN | 15982467 |
| e-ISSN | 20930429 |
| Journal | Journal of Bacteriology and Virology |
| Issue Number | 4 |
| Volume Number | 46 |
| Language | English |
| Publisher | Korean Society for Microbiology Korean Society of Virology |
| Publisher Date | 2016-01-01 |
| Publisher Place | Korea (South) |
| Access Restriction | Open |
| Subject Keyword | Discipline Microbiology Discipline Virology Discipline Infectious Diseases Discipline Bacteriology Cycloheximide Flavonoids Gallic Acid Ginsenosides Glycogen Synthase Hiv-1 Macrophages Microglia Oxidoreductases Phosphorylation Phosphotransferases Pyruvic Acid Original Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology |
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