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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Osorio-Rico, Laura Villeda-Hernández, Juana Santamaría, Abel Königsberg, Mina Galván-Arzate, Sonia |
| Description | Author Affiliation: Osorio-Rico L ( Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico Doctorado en Biología Experimental, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico Laboratorio de Bioenergética y Envejecimiento Celular, Departamento de Ciencias de la Salud, Unive); Villeda-Hernández J ( Laboratorio de Patología Experimental, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.); Santamaría A ( Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.); Königsberg M ( Laboratorio de Bioenergética y Envejecimiento Celular, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico.); Galván-Arzate S ( Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico absada@yahoo.com mkf@xanum.uam.mx sonia_galvan@yahoo.com.) |
| Abstract | Thallium (Tl(+)) is a toxic heavy metal capable of increasing oxidative damage and disrupting antioxidant defense systems. Thallium invades the brain cells through potassium channels, increasing neuronal excitability, although until now the possible role of glutamatergic transmission in this event has not been investigated. Here, we explored the possible involvement of a glutamatergic component in the Tl(+)-induced toxicity through the N-methyl-d-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) in rats. The effects of MK-801 (1 mg/kg, intraperitoneally [ip]) on early (24 hours) motor alterations, lipid peroxidation, reduced glutathione (GSH) levels, and GSH peroxidase activity induced by Tl(+) acetate (32 mg/kg, ip) were evaluated in adult rats. MK-801 attenuated the Tl(+)-induced hyperactivity and lipid peroxidation in the rat striatum, hippocampus and midbrain, and produced mild effects on other end points. Our findings suggest that glutamatergic transmission via NMDA receptors might be involved in the Tl(+)-induced altered regional brain redox activity and motor performance in rats. |
| File Format | HTM / HTML |
| ISSN | 10915818 |
| Issue Number | 6 |
| Volume Number | 34 |
| e-ISSN | 1092874X |
| Journal | International Journal of Toxicology |
| Language | English |
| Publisher | Sage Publication |
| Publisher Date | 2015-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Behavior, Animal Drug Effects Brain Chemistry Dizocilpine Maleate Therapeutic Use Excitatory Amino Acid Antagonists Receptors, N-methyl-d-aspartate Antagonists & Inhibitors Thallium Toxicity Animals Glutathione Metabolism Glutathione Peroxidase Injections, Intraperitoneal Lipid Peroxidation Male Motor Activity Psychomotor Performance Rats Rats, Wistar Synaptic Transmission Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology |
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