NDLI: Analysis of HLA-DM polymorphisms in the Chinese Han population.

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Analysis of HLA-DM polymorphisms in the Chinese Han population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Feng, M. L. Liu, R. Z. Shen, T. Zhao, Y. L. Zhu, Z. Y. Liu, D. Z.
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Feng ML ( Shanghai Blood Center, Shanghai, China.)
Abstract	Non-classical human leukocyte antigen (HLA)-DM plays an important and unique role in the processing and presentation of exogenous antigens. Polymorphisms of certain genes and frequency of alleles in populations may indicate susceptibility to certain diseases. In this study, the analysis of HLA-DMA and HLA-DMB gene polymorphisms and haplotypes in the Chinese Han population was conducted to obtain population genetic data. HLA-DM typing has been performed previously by other groups by polymerase chain reaction (PCR)-restriction fragment length polymorphism and PCR-sequence-specific oligonucleotide probe techniques. In this study, we established a TaqMan PCR typing method as an alternative to these techniques to survey the frequency of DMA and DMB alleles in the population. Genotyping was conducted in 1000 unrelated individuals of Han nationality in South and North China using TaqMan PCR typing. Four different DMA alleles and six different DMB alleles were detected. All loci met the Hardy-Weinberg equilibrium principle that both allele and genotype frequencies in a population remain constant. We found that the DMA01:01 (69.35%) and DMB01:01 (52.5%) alleles were more frequent in Chinese Hans. Analysis of the haplotypes for two loci of DMA and DMB showed that a highly significant positive linkage disequilibrium (LD) presented for DMA01:01-DMB01:02, DMA01:01-DMB01:03, DMA01:01-DMB01:04, DMA01:02-DMB01:01, DMA01:02-DMB01:05, DMA01:03-DMB01:07, and DMA01:04-DMB01:01 haplotypes. Analysis of haplotypes for four loci associated with antigen processing (DMA-DMB-TAP1-TAP2) showed a highly significant LD in DMA01:01-DMB01:04-TAP102:01:01-TAP201:02, DMA01: 02-DMB01:05-TAP101:01-TAP201:01, and DMA01:01-DMB01:03-TAP1* 04:01-TAP2*01:01 haplotypes. The comparison between the Chinese Han population and non-Chinese populations showed that no significant differences were found at the HLA-DMA locus in the Chinese Han population compared with people of German nationality, whereas significant differences presented when compared with Turkish, American Caucasian, Japanese, French, and Italian nationalities. However, at the HLA-DMB locus, highly significant differences presented in the Chinese Han population compared with Germans and Italians. This study lays the foundations for further disease association analyses.
File Format	HTM / HTML
ISSN	20592302
Issue Number	3
Volume Number	79
e-ISSN	20592310
Journal	Tissue Antigens
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Asian Continental Ancestry Group Genetics Hla-d Antigens Polymorphism, Genetic China Ethnology European Continental Ancestry Group Gene Frequency Blood Humans Polymerase Chain Reaction Polymorphism, Single Nucleotide Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology and Allergy Immunology

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