NDLI: The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms.

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The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nourse, Jamie P. Lea, Rod Crooks, Pauline Wright, Gillian Tran, Huyen Catalano, John Brighton, Tim Grigg, Andrew Marlton, Paula Gandhi, Maher K.
Description	Country affiliation: Australia Author Affiliation: Nourse JP ( Clinical Immunohaematology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.)
Abstract	Adult immune thrombocytopenia (ITP) is a heterogeneous disease and its immunobiology is incompletely understood. Establishing associations between candidate genes and ITP susceptibility may provide insight into pathogenesis. Previous studies have associated overrepresentation of FCGR3a-V158 allele with pediatric ITP. We prospectively accrued DNA from 102 adult patients with persistent/chronic or relapsed primary ITP identified by defined criteria. The distribution of KIR2 genes and polymorphisms of FCGR3a, both associated with autoimmunity, were compared with 105 healthy white individuals. Results were stratified by ethnicity. Carriers of the KIR2DS2/KIR2DL2 genotype [KIR2DS2/KIR2DL2 versus KIR2DS2/KIR2DL2 and KIR2DS2/KIR2DL2; odds ratio (OR) 2.51, P = 0.002] were overrepresented. In addition, frequency of the high-binding affinity FCGR3a-V/V158 genotype (VV versus VF/FF; OR = 3.05, P = 0.007) was increased, whereas that of the FCGR3a-F158 allele was reduced (OR = 2.58, P = 0.00.002). In a regression model to adjust for age, sex and the effects of the other gene, the KIR2 genotype independently conferred increased susceptibility from the FCGR3a-158 polymorphisms. In a comparison of healthy controls and a tightly defined cohort of adult ITP patients, the KIR2DS2/KIR2DL2 genotype was found to be associated with ITP independently of FCGR3a-158 polymorphisms. Further studies are required to establish the mechanistic basis for these observations and their potential impact on immune-based therapies.
File Format	HTM / HTML
ISSN	09575235
Issue Number	1
Volume Number	23
e-ISSN	14735733
Journal	Blood Coagulation & Fibrinolysis
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2012-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Hematology Purpura, Thrombocytopenic, Idiopathic Genetics Receptors, Igg Receptors, Kir2dl2 Receptors, Kir Adolescent Adult Aged Aged, 80 And Over Alleles Chronic Disease Female Genotype Humans Male Middle Aged Polymorphism, Genetic Prospective Studies Pathology Recurrence Young Adult Journal Article Multicenter Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Hematology

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