NDLI: HLA-A, -B and -DRB1 polymorphism in Koreans defined by sequence-based typing of 4128 cord blood units.

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HLA-A, -B and -DRB1 polymorphism in Koreans defined by sequence-based typing of 4128 cord blood units.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huh, J. Y. Yi, D. Y. Eo, S-H Cho, H. Park, M. H. Kang, M. S.
Spatial Coverage	Republic of Korea
Description	Author Affiliation: Huh JY ( Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea.)
Abstract	Human leucocyte antigen (HLA) alleles and haplotypes differ significantly among different ethnic groups, and high-resolution typing methods allow for the detection of a wider spectrum of HLA variations. In this study, HLA-A, -B and -DRB1 genotypes were analysed in 4128 cord blood units obtained from Korean women using the sequence-based typing method. A total of 44 HLA-A, 67 HLA-B and 48 HLA-DRB1 most probable alleles were identified. Of these, high-frequency alleles found at a frequency of ≥5% were 6 HLA-A (A02:01, A02:06, A11:01, A24:02, A31:01, A33:03), 5 HLA-B (B15:01, B44:03, B51:01, B54:01, B58:01) and 7 HLA-DRB1 (DRB101:01, DRB104:05, DRB107:01, DRB108:03, DRB109:01, DRB113:02, DRB115:01) alleles. At each locus, A02, B15 and DRB104 generic groups were most diverse at allelic level, consisting of 8, 11 and 10 different alleles, respectively. Two- and three-locus haplotypes estimated by the maximum likelihood method revealed 73 A-B, 74 B-DRB1 and 42 A-B-DRB1 haplotypes with frequencies of ≥0.3%. A total of 193 A-B-DRB1 haplotypes found at a frequency of ≥0.1% were presented, and the six most common haplotypes were A33:03-B44:03-DRB113:02 (4.6%), A33:03-B58:01-DRB113:02 (3.0%), A24:02-B07:02-DRB101:01 (2.7%), A33:03-B44:03-DRB107:01 (2.5%), A30:01-B13:02-DRB107:01 (2.2%) and A24:02-B52:01-DRB1*15:02 (2.1%). Compared with previous smaller scale studies, this study further delineated the allelic and haplotypic diversity in Koreans including low-frequency alleles and haplotypes. Information obtained in this study will be useful for the search for unrelated bone marrow donors and for anthropologic and disease association studies.
File Format	HTM / HTML
ISSN	17443121
Issue Number	6
Volume Number	40
e-ISSN	1744313X
Journal	International Journal of Immunogenetics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Hla-a Antigens Genetics Hla-b Antigens Hla-drb1 Chains Polymorphism, Genetic Alleles Asian Continental Ancestry Group Female Fetal Blood Metabolism Gene Frequency Genotype Haplotypes Humans Linkage Disequilibrium Polymerase Chain Reaction Republic Of Korea Sequence Analysis, Dna Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Immunology Genetics (clinical)

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HLA-A, -B and -DRB1 polymorphism in Koreans defined by sequence-based typing of 4128 cord blood units.

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