NDLI: HLA-A, B and DRB1 genetic heterogeneity in Quebec.

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HLA-A, B and DRB1 genetic heterogeneity in Quebec.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Buhler, S. Nunes, J. M. Sanchez-Mazas, A. Richard, L.
Spatial Coverage	Quebec
Description	Country affiliation: Switzerland Author Affiliation: Buhler S ( Laboratory of Anthropology, Genetics and Peopling history (AGP lab), Department of Genetics and Evolution - Anthropology Unit, University of Geneva, Geneva, Switzerland.)
Abstract	Recent studies have shown that under specific conditions such as high sample sizes and Hardy-Weinberg equilibrium, bone marrow donor registry data can be used to describe HLA molecular variation across a specific geographic area, thus providing excellent data sets to infer human migrations history. The province of Quebec is known to have experienced a complex history of settlement, characterized by multiple migrations and demographic changes. We thus analysed the data of more than 13 000 unrelated individuals acting as volunteer bone marrow donors who were molecularly typed for HLA-A, B and DRB1 polymorphisms in the Héma-Quebec registry. HLA allelic and haplotypic frequencies were estimated and compared among regions. The results indicate that, despite an overall low genetic diversity in Quebec, genetic variation is correlated with geography, compatible with isolation-by-distance across the province. However, some localities also harbour contrasting genetic profiles, that is a highly diversified genetic pool in the two main urban centres (Montréal and Laval) and a more pronounced genetic divergence of two specific regions characterized by a peculiar peopling history (Saguenay-Lac-St-Jean and Gaspésie-Îles-De-La-Madeleine). In agreement with other independent molecular markers, the observations based on HLA data thus account for the main demographic mechanisms that shaped the genetic structure of the present day Quebecer population. In addition, the detailed analysis of the Héma-Quebec registry provides key genetic information on which an efficient bone marrow transplantation recruitment strategy can be settled.
File Format	HTM / HTML
ISSN	17443121
Issue Number	2
Volume Number	42
e-ISSN	1744313X
Journal	International Journal of Immunogenetics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Genetic Heterogeneity Genetics, Population Hla-a Antigens Genetics Hla-b Antigens Hla-drb1 Chains Alleles Bone Marrow Transplantation Gene Frequency Genetic Variation Geography Immunology Haplotypes Histocompatibility Testing Humans Linkage Disequilibrium Molecular Typing Quebec Registries Tissue Donors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Immunology Genetics (clinical)

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