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| Content Provider | PubMed Central |
|---|---|
| Author | Shahani, Somayeh Mostafa, Rostamnezhad Vahid, Ghaffari-rad Ghasemi, Arash Allahverdi, Pourfallah Tayyeb Jalal, Hosseinimehr Seyed |
| Copyright Year | 2015 |
| Abstract | The radioprotective effect of Achillea millefolium L (ACM) extract was investigated against genotoxicity induced by ionizing radiation (IR) in human lymphocytes. Peripheral blood samples were collected from human volunteers and incubated with the methanolic extract of ACM at different concentrations (10, 50, 100, and 200 μg/mL) for 2 hours. At each dose point, the whole blood was exposed in vitro to 2.5 Gy of X-ray and then the lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis-blocked binucleated cell. Antioxidant capacity of the extract was determined using free radical-scavenging method. The treatment of lymphocytes with the extract showed a significant decrease in the incidence of micronuclei binucleated cells, as compared with similarly irradiated lymphocytes without any extract treatment. The maximum protection and decrease in frequency of micronuclei were observed at 200 μg/mL of ACM extract which completely protected genotoxicity induced by IR in human lymphocytes. Achillea millefolium extract exhibited concentration-dependent radical-scavenging activity on 1,1-diphenyl-2-picryl hydrazyl free radicals. These data suggest that the methanolic extract of ACM may play an important role in the protection of normal tissues against genetic damage induced by IR. |
| Related Links | http://dx.doi.org/10.1177/1559325815583761 |
| Starting Page | 1559325815583761 |
| File Format | |
| ISSN | 15593258 |
| e-ISSN | 15593258 |
| Journal | Dose-Response |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | SAGE Publications |
| Publisher Date | 2015-05-14 |
| Access Restriction | Open |
| Rights Holder | SAGE Publications |
| Subject Keyword | Toxicology Public Health, Environmental and Occupational Health Health, Toxicology and Mutagenesis Chemical Health and Safety Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Chemical Health and Safety |
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