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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tamura, Koji Ohgo, Shiro Yokoyama, Hitoshi |
| Description | Country affiliation: Japan Author Affiliation: Tamura K ( Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama Aoba-ku, Sendai 980-8578, Japan. tam@biology.tohoku.ac.jp) |
| Abstract | The limb blastema cell, which is a major source of mesenchymal components in the limb regenerate, serves as a stem cell that possesses an undifferentiated state and multipotency. A remarkable property of the limb blastema cell can be seen in its capability for morphogenesis. Elucidation of the molecular basis for morphological regeneration is essential for success in organ regeneration in humans, and characterization of limb blastema cells will provide many insights into how to create three-dimensional morphology during the regeneration process. In this review, we deal with positional memory, a key trait of the limb blastema cell in regard to morphological regeneration, making reference to classic surgical experiments, comparative descriptions of limb and fin blastemas, and genetic/epigenetic regulation of gene transcription. Urodele amphibians, anuran amphibians, and teleosts are likely to share fundamental mechanisms for morphological regeneration, but there are several differences in the process of regeneration, including the epigenetic conditions. Accumulation of knowledge of the molecular mechanisms and epigenetic modifications of gene activation in morphological regeneration of the model organisms for which an overview is provided in this review will lead to successful stimulation of regenerative capacity in amniotes, which only have a limited capability for morphological regeneration. |
| File Format | HTM / HTML |
| ISSN | 00121592 |
| Issue Number | 1 |
| Volume Number | 52 |
| e-ISSN | 1440169X |
| Journal | Development, Growth & Differentiation |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-01-01 |
| Publisher Place | Japan |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Embryology Discipline Biology Extremities Physiology Pluripotent Stem Cells Cytology Regeneration Animals Body Patterning Genetics Cell Differentiation Cell Proliferation Anatomy & Histology Gene Expression Regulation, Developmental Models, Biological Metabolism Vertebrates Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine |
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