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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sahin, Alparslan Kürsat Cingü, Abdullah Kaya, Savas Türkcü, Gül Ari, Seyhmus Evliyaoglu, Osman Çinar, Yasin Türkcü, Fatih Mehmet Yüksel, Harun Murat, Mehmet Çaça, Ihsan Gökalp, Osman |
| Description | Country affiliation: Turkey Author Affiliation: Sahin A ( Department of Ophthalmology, Dicle University, School of Medicine, Diyarbakir, Turkey. dralparslansahin@gmail.com) |
| Abstract | PURPOSE: This study intended to examine the effect of caffeic acid phenethyl ester (CAPE) on isoniazid (INH) and/or ethambutol (ETM)-induced retina and optic nerve toxicity in a rat model. METHODS: This study included eight groups, each containing 10 rats. The groups were Control, INH, ETM, CAPE, INH+CAPE, ETM+CAPE, INH+ETM and INH+ETM+CAPE. Rats were given orally 50 mg/kg/d of INH and 50 mg/kg/d of ETM in tap water for 30 d. 10 µmol/kg of CAPE were intraperitoneally injected for 30 d. The first dose of CAPE was given 24 h before the INH and ETM treatment and continued until sacrifice. Control group was given only tap water for 30 d. Rats were anaesthetized and sacrificed on the 30th day of experiment. Superoxide dismutase (SOD) activities, malondialdehyde (MDA), total anti-oxidant status (TAS), total oxidant status (TOS) were measured on the dissected and excised retina and optic nerve samples. Fellow eyes were used for histopathologic evaluation and the retinal ganglion cell (RGC) count. In addition, CAPE, INH and ETM interaction with SOD isoforms were calculated in silico. RESULTS: The SOD activity and TAS levels were found significantly higher in CAPE-treated groups compared to INH and/or ETM-treated groups (p < 0.0001). But the MDA, and TOS levels were significantly lower in CAPE-treated groups (p < 0.0001). The mean RGC count is significantly decreased in INH, ETM and INH+ETM groups compared with INH+CAPE, ETM+CAPE and INH+ETM+CAPE groups, respectively (p values 0.001, 0.042, and 0.001 respectively). Besides, in silico calculations showed that binding affinity of CAPE to SOD isotypes was higher than that of INH and ETM. CONCLUSION: This study demonstrates that CAPE treatment may decrease the oxidative stress in the retina and optic nerve of INH- and ETM-treated rats and may prevent RGC loss. As an underlying mechanism, CAPE and SOD interaction seems crucial for alleviation of ocular oxidative stress and RGCs toxicity. |
| File Format | HTM / HTML |
| ISSN | 15569527 |
| Issue Number | 3 |
| Volume Number | 32 |
| e-ISSN | 15569535 |
| Journal | Cutaneous and Ocular Toxicology |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2013-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ophthalmology Discipline Toxicology Discipline Dermatology Caffeic Acids Administration & Dosage Phenylethyl Alcohol Analogs & Derivatives Protective Agents Animals Ethambutol Adverse Effects Isoniazid Male Malondialdehyde Metabolism Optic Nerve Diseases Chemically Induced Oxidative Stress Drug Effects Rats Rats, Sprague-dawley Retinal Diseases Pathology Retinal Ganglion Cells Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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