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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ginis, Zeynep Ozturk, Gulfer Albayrak, Aynur Kurt, Sefika Nur Albayrak, Murat Fadillioglu, Ersin |
| Description | Country affiliation: Turkey Author Affiliation: Ginis Z ( Department of Clinical Biochemistry, Diskapi Training and Research Hospital, Ankara, Turkey drzeynepg@gmail.com.); Ozturk G ( Department of Clinical Biochemistry, Diskapi Training and Research Hospital, Ankara, Turkey.); Albayrak A ( Department of Pathology, Diskapi Training and Research Hospital, Ankara, Turkey.); Kurt SN ( Department of Physiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.); Albayrak M ( Department of Haematology, Diskapi Training and Research Hospital, Ankara, Turkey.); Fadillioglu E ( Department of Physiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.) |
| Abstract | BACKGROUND: The aim of this study was to establish the protective effect of caffeic acid phenethyl ester (CAPE) against the ifosfamide (IFOS)-induced central neurotoxicity in rats and to determine the changes in oxidant-antioxidant status of brain tissue. METHOD: A total of 35 Wistar rats (aged 7-12 days) were used in the experiments. The study comprised of five groups. Control untreated rats (n = 7) belonged to group 1; group 2 was given intraperitoneal (IP) injection of CAPE alone (10 µmol/kg; n = 7); group 3 was treated with single IP injection of IFOS (500 mg/kg; n = 7); group 4 was treated for 2 days with IP administration of CAPE (10 µmol/kg) beginning from one day before single IP injection of IFOS (n = 7); and group 5 was treated with saline and 10% ethanol. At the 24th hour of IFOS treatment, brain tissues were removed for analysis. RESULTS: The brain catalase activity was lower in IFOS group than the other groups (p < 0.05). The levels of malondialdehyde (MDA) and protein carbonyl content in brain tissue were higher in IFOS group than the control, CAPE, ethanol, and IFOS + CAPE groups (p < 0.05). There was no significant difference between MDA and protein carbonyl content of control, CAPE, ethanol, and IFOS + CAPE groups. Immunohistochemistry showed marked activation of caspase 3 in the IFOS group at 24 h after treatment. CONCLUSION: This study revealed that pretreatment with CAPE might protect brain tissue against IFOS-induced central neurotoxicity. CAPE could be an effective course of therapy to enhance therapeutic efficacy and to lessen IFOS toxicity in clinical chemotherapy. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 2 |
| Volume Number | 32 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2016-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Caffeic Acids Pharmacology Ifosfamide Toxicity Neurotoxicity Syndromes Drug Therapy Phenylethyl Alcohol Analogs & Derivatives Protective Agents Animals Antioxidants Brain Drug Effects Metabolism Catalase Immunohistochemistry Lipid Peroxidation Male Malondialdehyde Oxidative Stress Protein Carbonylation Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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