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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Su, Chun-Han Lu, Tzy-Ming Lai, Min-Nan Ng, Lean-Teik |
| Description | Country affiliation: Taiwan Author Affiliation: Su CH ( Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan.) |
| Abstract | This study examined the inhibitory effects of Grifola frondosa (GF), a medicinal mushroom popularly consumed in traditional medicine and health food, on digestive enzymes related to type 2 diabetes; chemical profiles and inhibitory kinetics of its bioactive fractions were also analyzed. Results showed that all GF extracts showed weak anti- -amylase activity; however, strong anti- -glucosidase activity was noted on GF n-hexane extract (GF-H). Further fractionation confirmed that compared with acarbose (a commercial -glucosidase inhibitor), the nonpolar fraction of GF possessed a stronger anti- -glucosidase activity but a weaker anti- -amylase activity. These activities were not derived from ergosterol and ergosterol peroxide, two major compounds of this fraction. The inhibitory kinetics of GF-H on -glucosidase was competitive inhibition. GF-H was as good as acarbose in inhibiting the starch digestion in vitro. Oleic acid and linoleic acid could be the major active constituents that have contributed to the potency of GF in inhibiting -glucosidase activity. |
| File Format | HTM / HTML |
| ISSN | 08854513 |
| Issue Number | 4 |
| Volume Number | 60 |
| e-ISSN | 14708744 |
| Journal | Biotechnology and Applied Biochemistry |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Biotechnology Enzyme Inhibitors Pharmacology Glycoside Hydrolase Inhibitors Grifola Chemistry Hyperglycemia Drug Therapy Enzymology Alpha-amylases Antagonists & Inhibitors Digestion Drug Effects Therapeutic Use Hydrolysis Kinetics Starch Metabolism Alpha-glucosidases Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Drug Discovery Molecular Medicine Bioengineering Biomedical Engineering Applied Microbiology and Biotechnology Biotechnology Process Chemistry and Technology |
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