NDLI: Hepatic Tumor Metastases Cause Enhanced PEGylated Liposome Uptake by Kupffer Cells.

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Hepatic Tumor Metastases Cause Enhanced PEGylated Liposome Uptake by Kupffer Cells.

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Hepatic Tumor Metastases Cause Enhanced PEGylated Liposome Uptake by Kupffer Cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ukawa, Masami Fujiwara, Yukako Ando, Hidenori Shimizu, Taro Ishida, Tatsuhiro
Description	Author Affiliation: Ukawa M ( Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Biomedical Sciences, Tokushima University.)
Abstract	Kupffer cells in livers bearing tumor metastases were found to have promoted tumor invasion and exacerbated the metastasis. This implies that the function of Kupffer cells might differ between animals bearing hepatic metastases and those that are healthy. Kupffer cells are considered responsible for the accumulation of liposomes in the liver. In this study, we hypothesized that the alteration in the function of Kupffer cells by hepatic metastasis would also affect the biodistribution of liposomes following intravenous administration. The hepatic accumulation and the blood concentration of PEGylated liposomes were compared between healthy mice and tumor-bearing mice. We noted that hepatic accumulation and elimination from the blood were significantly accelerated in tumor-bearing mice, indicating that our hypothesis was correct. In the tumor-bearing mice, the proportion of Kupffer cells taking up liposomes was significantly increased. Intravenous injection of oxaliplatin (l-OHP) containing PEGylated liposomes decreased the fraction of Kupffer cells, but this administration caused no injury to the hepatocytes. These results suggest that PEGylated liposomes containing l-OHP may have the potential to treat metastatic hepatic cancer-not only via the direct killing of the cancer cells but also via a reduction in tumor-supportive Kupffer cells.
File Format	HTM / HTML
ISSN	09186158
e-ISSN	13475215
Journal	Biological & Pharmaceutical Bulletin
Issue Number	2
Volume Number	39
Language	English
Publisher	The Pharmaceutical Society of Japan J-STAGE
Publisher Date	2016-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Discipline Pharmacology Kupffer Cells Metabolism Liver Neoplasms Neoplasms, Experimental Pathology Animals Antineoplastic Agents Biological Transport Drug Effects Cells, Cultured Liposomes Mice Neoplasm Metastasis Organoplatinum Compounds Polyethylene Glycols Sarcoma Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology Pharmaceutical Science

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