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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Song, Ji-Won Seo, Chang-Seob Kim, Tae-In Moon, Og-Sung Won, Young-Suk Son, Hwa-Young Son, Jong-Keun Kwon, Hyo-Jung |
| Description | Author Affiliation: Song JW ( Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University.) |
| Abstract | Manassantin A, a neolignan isolated from Saururus chinensis, is a major phytochemical compound that has various biological activities, including anti-inflammatory, neuroleptic, and human acyl-CoA : cholesterol acyltransferase (ACAT) inhibitory activities. In this study, we investigated the protective effects of manassantin A against ethanol-induced acute gastric injury in rats. Gastric injury was induced by intragastric administration of 5 mL/kg body weight of absolute ethanol to each rat. The positive control group and the manassantin A group were given oral doses of omeprazole (20 mg/kg) or manassantin A (15 mg/kg), respectively, 1 h prior to the administration of absolute ethanol. Our examinations revealed that manassantin A pretreatment reduced ethanol-induced hemorrhage, hyperemia, and epithelial cell loss in the gastric mucosa. Manassantin A pretreatment also attenuated the increased lipid peroxidation associated with ethanol-induced acute gastric lesions, increased the mucosal glutathione (GSH) content, and enhanced the activities of antioxidant enzymes. The levels of pro-inflammatory cytokines, tumor necrosis factor- (TNF- ), interleukin (IL)-6, and IL-1ß were clearly decreased in the manassantin A-pretreated group. In addition, manassantin A pretreatment enhanced the levels of cyclooxygenase (COX)-1, COX-2, and prostaglandin E2 (PGE2) and reduced the inducible nitric oxide synthase (iNOS) overproduction and nuclear factor kappa B (NF-κB) phosphorylation. Collectively, these results indicate that manassantin A protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB activation, and improvements in the antioxidant and anti-inflammatory status. |
| File Format | HTM / HTML |
| ISSN | 09186158 |
| e-ISSN | 13475215 |
| Journal | Biological & Pharmaceutical Bulletin |
| Issue Number | 2 |
| Volume Number | 39 |
| Language | English |
| Publisher | The Pharmaceutical Society of Japan J-STAGE |
| Publisher Date | 2016-01-01 |
| Publisher Place | Japan |
| Access Restriction | Open |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Anti-ulcer Agents Pharmacology Lignans Stomach Diseases Chemically Induced Animals Chemistry Catalase Ethanol Glutathione Malondialdehyde Molecular Structure Omeprazole Rats, Sprague-dawley Saururaceae Prevention & Control Superoxide Dismutase Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Pharmacology Pharmaceutical Science |
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