NDLI: Gender-specific association between ACE gene I/D polymorphism and blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients.

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Gender-specific association between ACE gene I/D polymorphism and blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients.

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Gender-specific association between ACE gene I/D polymorphism and blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Yun Yang, Peng Wu, Shouling Yuan, Juxiang Shen, Chong Wu, Ying Zhao, Dandan Ren, Qi Feng, Fumin Guan, Weijun
Description	Country affiliation: China Author Affiliation: Li Y ( School of Public Health, Hebei United University, Tangshan 063007, China. liyun8022@gmail.com)
Abstract	To evaluate the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and gender with individual blood pressure response to hydrochlorothiazide (HCTZ) in hypertensives, we enrolled 829 mild-moderate hypertensive patients. All subjects were given HCTZ (12.5 mg) orally each day for 6 weeks. A total of 776 patients completed the study. There was statistically significant interaction between the effects of genotype and gender on systolic (P = 0.002) and diastolic (P = 0.048) response after adjusting for covariables. Moreover, in each gender, the genotype that was associated with the greatest blood pressure response to HCTZ (DD homozygotes in men and II homozygotes in women) was also associated with the greatest increase in serum ACE activity in response to HCTZ. The results suggest that the I/D polymorphism of the ACE gene is associated with interindividual differences in the blood pressure response to a low dose of a diuretic in a gender-specific manner in the Han Chinese population with hypertension.
File Format	HTM / HTML
ISSN	00062928
Issue Number	11-12
Volume Number	49
e-ISSN	15734927
Journal	Biochemical Genetics
Language	English
Publisher	Springer
Publisher Date	2011-12-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Molecular Biology Antihypertensive Agents Pharmacology Asian Continental Ancestry Group Blood Pressure Drug Effects Hydrochlorothiazide Hypertension Drug Therapy Peptidyl-dipeptidase A Genetics Polymorphism, Genetic Adult Aged Female Gene Frequency Genotype Humans Enzymology Male Middle Aged Sex Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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