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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Song-Yan Sima, Xiutian Wang, Chun-Hui Gao, Ming |
| Description | Author Affiliation: Liu SY ( The Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, PR China.) |
| Abstract | OBJECTIVES: Angiotensin I-converting enzyme (ACE) plays crucial roles not only in the regulation of circulatory homeostasis but also in the pathology of carcinomas. An insertion-deletion (I/D) polymorphism in intron 16 of ACE gene was identified to be functional. We aimed to investigate the association between ACE I/D polymorphism and risk of colorectal cancer (CRC). DESIGN AND METHODS: Using genomic DNA from 241 CRC patients and 299 control subjects, we genotyped the ACE I/D polymorphism using a polymerase chain reaction analysis. RESULTS: We found that patients carrying the D allele were associated with an increased risk of developing poorly differentiated cancer and metastasis compared with those carrying the I allele (OR=1.54, 95%CI, 1.04-2.28; OR=1.56, 95%CI, 1.08-2.26, respectively), although no significant association was observed between cases and controls in overall analysis. CONCLUSIONS: These findings indicate that the ACE I/D polymorphism is likely to play a role in CRC progression. |
| File Format | HTM / HTML |
| ISSN | 00099120 |
| Issue Number | 14-15 |
| Volume Number | 44 |
| e-ISSN | 18732933 |
| Journal | Clinical Biochemistry |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Asian Continental Ancestry Group Genetics Colorectal Neoplasms Peptidyl-dipeptidase A Polymorphism, Genetic Aged Case-control Studies Pathology Female Gene Frequency Genetic Predisposition To Disease Humans Male Middle Aged Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Clinical Biochemistry |
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