NDLI: Conserved or Lost: Molecular Evolution of the Key Gene GULO in Vertebrate Vitamin C Biosynthesis

Please wait, while we are loading the content...

Year: 2016 Volume: 54

Year: 2015 Volume: 53

Year: 2014 Volume: 52

Year: 2013 Volume: 51

Year: 2013 Volume: 51 Issue: 1-2

Year: 2013 Volume: 51 Issue: 3-4

Year: 2013 Volume: 51 Issue: 5-6

LEI0258 microsatellite variability in Khorasan, Marandi, and Arian chickens.

Molecular cloning and expression analysis of the starch-branching enzyme III gene from common wheat (Triticum aestivum ).

Biochemical Evaluation of Triploid Progenies of Diploid × Tetraploid Breeding Populations of Camellia for Genotypes Rich in Catechin and Caffeine

Molecular mapping and characterization of genes governing time to flowering, seed weight, and plant height in an intraspecific genetic linkage map of chickpea (Cicer arietinum).

Association between apolipoprotein E gene polymorphism and myocardial infarction.

Evaluation of fecal storage and DNA extraction methods in wild boar (Sus scrofa).

Conserved or Lost: Molecular Evolution of the Key Gene GULO in Vertebrate Vitamin C Biosynthesis

Carbonic anhydrase-related protein XI: structure of the gene in the greater false vampire bat (Megaderma lyra) compared with human and domestic pig.

Genetic diversity of selected Iranian quinces using SSRs from apples and pears.

Molecular characterization and expression analysis of heat shock cognate 70 after heat stress and lipopolysaccharide challenge in sea cucumber (Apostichopus japonicus).

GT microsatellite repeats in the heme oxygenase-1 gene promoter associated with abdominal aortic aneurysm in Croatian patients.

Repeats in transforming acidic coiled-coil (TACC) genes.

Year: 2013 Volume: 51 Issue: 7-8

Year: 2013 Volume: 51 Issue: 9-10

Year: 2013 Volume: 51 Issue: 11-12

Year: 2012 Volume: 50

Year: 2011 Volume: 49

Year: 2010 Volume: 48

Year: 2009 Volume: 47

Year: 2008 Volume: 46

Year: 2006 Volume: 44

Conserved or Lost: Molecular Evolution of the Key Gene GULO in Vertebrate Vitamin C Biosynthesis

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Hongwen
Description	Country affiliation: China Author Affiliation: Yang H ( Biology Department, Zhangzhou Normal University, 36 Xian Qian Zhi Street, Zhangzhou 363000, Fujian, China. hwyang2002@sina.com)
Abstract	l-gulono-gamma-lactone oxidase (GULO) catalyzes the final step in vertebrate vitamin C biosynthesis. Vitamin C-incapable vertebrates lack the GULO gene. Gene structure and phylogenetic analyses showed that vertebrate GULO genes are 64–95% identical at the amino acid level and consist of 11 conserved exons. GULO pseudogenes have multiple indel mutations and premature stop codons in higher primates, guinea pigs, and some bats. No GULO-like sequences were identified in teleost fishes. During animal GULO evolution, exon F was subdivided into F1 and F2. Additional GULO retropseudogenes were identified in dogs, cats, and giant pandas. GULO-flanking genome regions acquired frequent segment translocations and inversions during vertebrate evolution. Purifying selection was detected across vertebrate GULO genes (d $_{N}/d$ $_{S} = 0.069),$ except for some positively selected sites identified in sharks and frogs. These positive sites demonstrated little functional significance when mapped onto the three-dimensional GULO protein structure. Vertebrate GULO genes are conserved except for those that are lost.
File Format	HTM / HTML
ISSN	00062928
Issue Number	5-6
Volume Number	51
e-ISSN	15734927
Journal	Biochemical Genetics
Language	English
Publisher	Springer
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Molecular Biology Ascorbic Acid Biosynthesis Conserved Sequence Genetics Evolution, Molecular L-gulonolactone Oxidase Vertebrates Animals Base Sequence Cats Dogs Exons Genome Humans Introns Models, Molecular Molecular Sequence Data Phylogeny Pseudogenes Selection, Genetic Sequence Homology, Nucleic Acid Sequence Inversion Translocation, Genetic Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in