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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gupta, Sanjay Kumar Baghel, Madhav Singh Bhuyan, Chaturbhuja Ravishankar, B. Ashok, B. K. Patil, Panchakshari D. |
| Description | Country affiliation: India Author Affiliation: Gupta SK ( Associate Professor and I/C Head, Department of Shalya Tantra, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.) |
| Abstract | Population in an industrialized world is afflicted by urinary stone disease. Kidney stones are common in all kinds of urolithiasis. One distinguished formulation mentioned by Sushruta for management of Ashmari (urolithiasis) is Pashanabhedadi Ghrita (PBG), which is in clinical practice since centuries. Validation of drug is the requirement of time through the experimental study. In this study, trial of PBG has been made against ammonium oxalate rich diet and gentamicin injection induced renal calculi in albino rats. The calculi were induced by gentamicin injection and ammonium oxalate rich diet. Test drug was administered concomitantly in the dose of 900 mg/kg for 15 consecutive days. Rats were sacrificed on the 16(th) day. Parameters like kidney weight, serum biochemical, kidney tissue and histopathology of kidney were studied. Concomitant treatment of PBG attenuates blood biochemical parameters non-significantly, where as it significantly attenuated lipid peroxidation and enhanced glutathione and glutathione peroxidase activities. It also decreased crystal deposition markedly into the renal tubules in number as well as size and prevented damage to the renal tubules. The findings showed that PBG is having significant anti-urolithiatic activities against ammonium oxalate rich diet plus gentamicine injection induced urolithiasis in rats. |
| File Format | HTM / HTML |
| ISSN | 09748520 |
| e-ISSN | 09769382 |
| DOI | 10.4103/0974-8520.108860 |
| Journal | AYU (An International Quarterly Journal of Research in Ayurveda) |
| Issue Number | 3 |
| Volume Number | 33 |
| Language | English |
| Publisher | Medknow Publications |
| Publisher Date | 2012-07-01 |
| Publisher Place | India |
| Access Restriction | Open |
| Subject Keyword | Discipline Naturopathy |
| Content Type | Text |
| Resource Type | Article |
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