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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gerrits, Han Van Ingen Schenau, Dorette S. Bakker, Nicole E. C. Van Disseldorp, Ad J. M. Strik, Ankie Hermens, Laura S. Koenen, Tim B. Krajnc-Franken, Magda A. M. Gossen, Jan A. |
| Description | Country affiliation: Netherlands Author Affiliation: Gerrits H ( N.V. Organon, part of Schering-Plough Corporation, Target Discovery, Molenstraat 110, 5340 BH Oss, The Netherlands.) |
| Abstract | CXCR7 is a G-protein coupled receptor that was recently deorphanized and shown to have SDF1 and I-TAC as high affinity ligands. Here we describe the characterization of CXCR7-deficient mice that were generated to further investigate the function of this receptor in vivo. Expression analysis using a LacZ reporter knockin revealed that postnatally Cxcr7 was specifically expressed in cardiomyocytes, vascular endothelial cells of the lung and heart, the cerebral cortex and in osteocytes of the bone. Adult tissues revealed high expression in cardiomyocytes and osteocytes. The observation that 70% of the Cxcr7-/- mice died in the first week after birth coincides with expression of Cxcr7 in vascular endothelial cells and in cardiomyocytes. An important role of CXCR7 in the cardiovascular system was further supported by the observation that hearts of the Cxcr7-/- mice were enlarged, showed myocardial degeneration and fibrosis of postnatal origin, and hyperplasia of embryonic origin. Despite high expression in osteocytes no apparent bone phenotype was observed, neither in combination with ovariectomy nor orchidectomy. Thus as CXCR7 does not seem to play an important role in bone our data indicate an important function of CXCR7 in the cardiovascular system during multiple steps of development. |
| File Format | HTM / HTML |
| ISSN | 1526954X |
| Issue Number | 5 |
| Volume Number | 46 |
| e-ISSN | 1526968X |
| Journal | genesis |
| Language | English |
| Publisher | Wiley-Liss |
| Publisher Date | 2008-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Genetics Discipline Developmental Biology Discipline Embryology Cardiovascular Abnormalities Genetics Mortality Genes, Lethal Receptors, G-protein-coupled Deficiency Animals Animals, Newborn Bone And Bones Embryology Cardiovascular System Female Gene Transfer Techniques Male Mice Mice, Knockout Receptors, Cxcr Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Genetics Medicine Endocrinology |
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