NDLI: Successful treatment of canine necrolytic migratory erythema (superficial necrolytic dermatitis) due to metastatic glucagonoma with octreotide.

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Successful treatment of canine necrolytic migratory erythema (superficial necrolytic dermatitis) due to metastatic glucagonoma with octreotide.

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Successful treatment of canine necrolytic migratory erythema (superficial necrolytic dermatitis) due to metastatic glucagonoma with octreotide.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oberkirchner, Ursula Linder, Keith E. Zadrozny, Leah Olivry, Thierry
Description	Country affiliation: United States Author Affiliation: Oberkirchner U ( Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.)
Abstract	Necrolytic migratory erythema (NME; also known as superficial necrolytic dermatitis) is a syndrome most often associated with certain chronic liver diseases or pancreatic glucagonomas. In humans with glucagonoma-associated NME, skin lesions usually respond to octreotide, a somatostatin analogue that inhibits glucagon release. In this report an 11-year-old golden retriever dog with pancreatic glucagonoma and metastasis to the regional lymph nodes, spleen and liver was diagnosed with NME. The dog exhibited erosions, ulcers and crusts on the paws, pressure points, muzzle, periocular area and prepuce. The dog was also anorexic and had difficulty walking. Because metastasis precluded surgery, treatment was initiated with subcutaneous octreotide (2 µg/kg twice daily). Skin lesions and systemic clinical signs improved markedly within 5 days. The dosage was increased to nearly 3 µg/kg twice daily and signs almost completely resolved within 10 days. Anorexia was the major adverse effect observed. During the following month, both dosage (1-3.7 µg/kg) and frequency (two to four times daily) of the octreotide injections were adjusted to permit control of clinical signs while maintaining adequate appetite. Temporary cessation of octreotide administration resulted in the rapid recurrence of skin lesions. Resuming injections led to improvement of clinical signs within 48 h. The dog was later euthanized because of progressive metastatic disease. In conclusion, subcutaneous octreotide injections were beneficial in this dog with glucagonoma-associated NME. This somatostatin analogue could be a valuable option to treat canine patients with non-resectable or relapsing pancreatic glucagonoma-associated NME.
File Format	HTM / HTML
ISSN	09594493
Issue Number	5
Volume Number	21
e-ISSN	13653164
Journal	Veterinary Dermatology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Veterinary Medicine Discipline Dermatology Dog Diseases Drug Therapy Glucagonoma Veterinary Necrolytic Migratory Erythema Octreotide Therapeutic Use Pancreatic Neoplasms Animals Anorexia Chemically Induced Antineoplastic Agents, Hormonal Administration & Dosage Adverse Effects Dogs Dose-response Relationship, Drug Complications Pathology Lymph Nodes Male Paraneoplastic Syndromes Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Veterinary

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