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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sonne, Si B. Perrett, Rebecca M. Nielsen, John E. Baxter, Melissa A. Kristensen, David M. Leffers, Henrik Hanley, Neil A. Rajpert-De-Meyts, Ewa |
| Description | Country affiliation: Denmark Author Affiliation: Sonne SB ( University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.) |
| Abstract | The transcriptional regulators of pluripotency, POU5F1 (OCT4), NANOG and SOX2, are highly expressed in embryonal carcinoma (EC). In contrast to OCT4 and NANOG, SOX2 has not been demonstrated in the early human germ cell lineage or carcinoma in situ (CIS), the precursor for testicular germ cell tumours (TGCTs). Here, we have analysed SOX2 expression in CIS and overt TGCTs, as well as normal second and third trimester fetal, prepubertal and adult testes by in situ hybridisation and immunohistochemistry using three different antibodies. In contrast to earlier studies, we detected SOX2 mRNA in most CIS cells. We also detected speckled nuclear SOX2 immunoreactivity in CIS cells with one primary antibody, which was not apparent with other primary antibodies. The results demonstrate SOX2 gene expression in CIS for the first time and raise the possibility of post-transcriptional regulation, most likely sumoylation as a mechanism for limiting SOX2 action in these cells. |
| File Format | HTM / HTML |
| ISSN | 02146282 |
| e-ISSN | 16963547 |
| DOI | 10.1387/ijdb.082668ss |
| Journal | The International Journal of Developmental Biology |
| Issue Number | 4 |
| Volume Number | 54 |
| Language | English |
| Publisher | University of the Basque Country Press |
| Publisher Date | 2010-01-01 |
| Publisher Place | Spain |
| Access Restriction | Open |
| Subject Keyword | Discipline Embryology Discipline Biology Germ Cells Metabolism Neoplasms, Germ Cell And Embryonal Soxb1 Transcription Factors Testicular Neoplasms Testis Carcinoma, Embryonal Genetics Cell Line Gene Expression Genes Chemistry Immunohistochemistry Rna, Messenger Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental Biology Embryology |
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