NDLI: Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells.

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Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells.

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Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chang, Eun-Ah Beyhan, Zeki Yoo, Myung-Sik Siripattarapravat, Kannika Ko, Tak Lookingland, Keith J. Madhukar, Burra V. Cibelli, Jose B.
Description	Country affiliation: United States Author Affiliation: Chang EA ( Animal Science, Michigan State University, East Lansing, MI 48824, USA.)
Abstract	Previous reports have shown that antidepressants increase neuronal cell proliferation and enhance neuroplasticity both in vivo and in vitro. This study investigated the direct effects of one such antidepressant, fluoxetine , on cell proliferation and on the production of neurotrophic factors in neuronal precursors derived from human embryonic stem cells (hESCs; H9). Fluoxetine induced the differentiation of neuronal precursors, strongly enhancing neuronal characteristics. The rate of proliferation was higher in fluoxetine -treated cells than in control cells, as determined by MTT [3(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide] assay. The CPDL (cumulative population doubling level) of the fluoxetine-treated cells was significantly increased in comparison to that of control cells (p<.001). Bromodeoxyuridine incorporation and staurosporine-induced apoptosis assays were elevated in fluoxetine-treated cells. Quantitative RT-PCR analysis revealed no significant differences in the expression of neurotrophic factors, brain-derived neurotrophic factor (BDNF);glial-derived neurotrophic factor (GDNF) and cAMP-responsive element-binding protein (CREB) between cells treated with fluoxetine for two weeks and their untreated counterparts. These results may help elucidate the mechanism of action of fluoxetine as a therapeutic drug for the treatment of depression. Data presented herein provide more evidence that, in addition to having a direct chemical effect on serotonin levels, fluoxetine can influence hESC-derived neuronal cells by increasing cell proliferation, while allowing them to maintain their neuronal characteristics.
File Format	HTM / HTML
ISSN	02146282
e-ISSN	16963547
Journal	The International Journal of Developmental Biology
Issue Number	4
Volume Number	54
Language	English
Publisher	University of the Basque Country Press
Publisher Date	2010-01-01
Publisher Place	Spain
Access Restriction	Open
Subject Keyword	Discipline Embryology Discipline Biology Antidepressive Agents, Second-generation Pharmacology Embryonic Stem Cells Physiology Fluoxetine Neurons Apoptosis Drug Effects Brain-derived Neurotrophic Factor Genetics Metabolism Bromodeoxyuridine Cell Differentiation Cell Line Cell Proliferation Cyclic Amp Response Element-binding Protein Depressive Disorder Embryo, Mammalian Nerve Growth Factors Neuronal Plasticity Reverse Transcriptase Polymerase Chain Reaction Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Embryology

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