NDLI: Catabolite repression control of flagellum production by Serratia marcescens.

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Catabolite repression control of flagellum production by Serratia marcescens.

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Year: 2008 Volume: 159 Issue: 9-10

Year: 2007 Volume: 158

Year: 2005 Volume: 156

Catabolite repression control of flagellum production by Serratia marcescens.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stella, Nicholas A. Kalivoda, Eric J. O'Dee, Dawn M. Nau, Gerard J. Shanks, Robert M. Q.
Description	Country affiliation: United States Author Affiliation: Stella NA ( Charles T. Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, EEI 1020, 203 Lothrop Street, Pittsburgh, PA 15213, USA. stellan@upmc.edu)
Abstract	Serratia marcescens is an emerging opportunistic pathogen with a remarkably broad host range. The cAMP-regulated catabolite repression system of S. marcescens has recently been identified and demonstrated to regulate biofilm formation through the production of surface adhesions. Here we report that mutations in components of the catabolite repression system (cyaA and crp) eliminate flagellum production and swimming motility. Exogenous cAMP was able to restore flagellum production to adenylate cyclase mutants, as determined by transmission electron microscopy and PAGE analysis. A transposon-generated suppressor mutation of the crp motility defect mapped to upstream of the flhDC operon. This suppressor mutation resulted in an upregulation of flhD expression and flagellum production, indicating that flhDC expression is sufficient to restore flagellum production to crp mutants. Lastly, and contrary to a previous report, we found that flhD expression is controlled by the catabolite repression system using quantitative RT-PCR. Together, these data indicate that flagellum production is regulated by the cAMP-dependent catabolite repression system. Given the role of flagella in bacterial pathogenicity, the regulatory pathway described here may assist us in better understanding the putative role of motility in dissemination and virulence of this opportunistic pathogen.
File Format	HTM / HTML
ISSN	09232508
e-ISSN	17697123
DOI	10.1016/j.resmic.2008.07.003
Journal	Research in Microbiology
Issue Number	7-8
Volume Number	159
Language	English
Publisher	Elsevier
Publisher Date	2008-09-01
Publisher Place	France
Access Restriction	Open
Subject Keyword	Discipline Microbiology Bacterial Proteins Metabolism Cyclic Amp Receptor Protein Down-regulation Flagella Genetics Serratia Marcescens Physiology Ultrastructure Gene Expression Regulation, Bacterial Microscopy, Electron, Transmission Mutation Serratia Infections Microbiology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Microbiology

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