NDLI: Comparative study of the stability of venlafaxine hydrochloride sustained-release pellets prepared by double-polymer coatings and hot-melt subcoating combined with Eudragit(®) NE30D outercoating.

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Comparative study of the stability of venlafaxine hydrochloride sustained-release pellets prepared by double-polymer coatings and hot-melt subcoating combined with Eudragit(®) NE30D outercoating.

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Comparative study of the stability of venlafaxine hydrochloride sustained-release pellets prepared by double-polymer coatings and hot-melt subcoating combined with Eudragit(®) NE30D outercoating.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guan, Tingting Wang, Jing Li, Guofei Tang, Xing
Description	Author Affiliation: Guan T ( Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, PR China.)
Abstract	The aim of this paper was to study the comparative stability of venlafaxine hydrochloride (VEN) sustained-release pellets prepared by double-polymer coatings and hot-melt subcoating combined Eudragit(®) NE30D outercoating. The uncoated VEN pellets, containing 45% (w/w) VEN, 45% (w/w) MCC (PH101), 10% (w/w) stearic acid and 0.5% (w/w) Carbopol974, were prepared by extrusion-spheronization. Satisfactory release profiles were obtained when VEN pellets were prepared by 4% EC subcoating combined with 4% Eudragit(®) NE30D outercoating and 8% hot-melt subcoating combined with 6% Eudragit(®) NE30D outercoating, respectively. The storage stability was monitored by measuring the drug release over six months storage at 40°C/75% RH and at room temperature (25 ± 2°C/60% RH). The release of pellets with double-polymer coatings increased markedly, while drug release of pellets prepared by hot-melt subcoating combined with polymer coating gradually decreased. Basically, the former may be attributed to the main role of drug migration into the EC subcoating, and the latter may be caused by the fusion and resolidification of stearic acid particles and the further aging of the Eudragit(®) NE30D outercoating. In summary, regardless of the change in release, drug dissolution met the standard requirement and the stability was acceptable during the storage period.
File Format	HTM / HTML
ISSN	10837450
Issue Number	3
Volume Number	16
e-ISSN	10979867
Journal	Pharmaceutical Development and Technology
Language	English
Publisher	Taylor & Francis
Publisher Date	2011-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Cyclohexanols Chemistry Delayed-action Preparations Drug Compounding Methacrylates Polymers Chemistry, Pharmaceutical Drug Stability Drug Storage Excipients Hot Temperature Microscopy, Electron, Scanning Solubility Venlafaxine Hydrochloride Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmaceutical Science

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