NDLI: Investigating effect of microemulsion components: In vitro permeation of ketoconazole.

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Investigating effect of microemulsion components: In vitro permeation of ketoconazole.

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Investigating effect of microemulsion components: In vitro permeation of ketoconazole.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Patel, Mrunali R. Patel, Rashmin B. Parikh, Jolly R. Solanki, Ajay B. Patel, Bharat G.
Description	Country affiliation: India Author Affiliation: Patel MR ( Indukaka Ipcowala College of Pharmacy, Vallabh Vidyanagar, India. rashmru@gmail.com)
Abstract	The purpose of this study was to evaluate the effect of oil, surfactant/co-surfactant mixing ratios and water on the in vitro permeation of ketoconazole (KTZ) applied in O/W microemulsion vehicle through intact rat skin. Lauryl Alcohol (LA) was screened as the oil phase of microemulsions, due to a good solubilizing capacity of the microemulsion system. The pseudo-ternary phase diagrams for microemulsion regions were constructed using LA as the oil, Labrasol (Lab) as the surfactant (S) and ethanol (EtOH) as the cosurfactant (CoS). The formulation which showed a highest permeation rate of 54.65 ± 1.72 µg/cm(2)/h(1) and appropriate physico-chemical properties was optimized as containing 2% KTZ, 10% LA, 20% Lab/EtOH (1:1) and 68% double distilled water (w/w). The efficiency of microemulsion formulation in the topical delivery of KTZ was dependent upon the contents of water and LA as well as Lab/EtOH mixing ratio. It was concluded that the percutaneous absorption of KTZ from microemulsions was enhanced with increasing the LA and water contents, and with decreasing the Lab/EtOH ratio in the formulation. Candida albicans was used as a model fungus to evaluate the antifungal activity of the best formula achieved, which showed the widest zone of inhibition as compared to KTZ reference. The studied microemulsion formulation showed a good stability for a period of three months. Histopathological investigation of rat skin revealed the safety of microemulsion formulations for topical use. These results indicate that the studied microemulsion formulation might be a promising vehicle for topical delivery of KTZ.
File Format	HTM / HTML
ISSN	10837450
Issue Number	3
Volume Number	16
e-ISSN	10979867
Journal	Pharmaceutical Development and Technology
Language	English
Publisher	Taylor & Francis
Publisher Date	2011-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Antifungal Agents Administration & Dosage Emulsions Chemistry Ketoconazole Skin Absorption Drug Effects Animals Pharmacokinetics Candida Albicans Chemistry, Pharmaceutical Drug Delivery Systems Drug Stability Excipients Male Oils Rats Rats, Wistar Surface-active Agents Water Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmaceutical Science

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