NDLI: Glycemic control and high-density lipoprotein characteristics in adolescents with type 1 diabetes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Medina-Bravo, Patricia Medina-Urrutia, Aída Juárez-Rojas, Juan Gabriel Cardoso-Saldaña, Guillermo Jorge-Galarza, Esteban Posadas-Sánchez, Rosalinda Coyote-Estrada, Ninel Nishimura-Meguro, Elisa Posadas-Romero, Carlos
Description	Country affiliation: Mexico Author Affiliation: Medina-Bravo P ( Department of Endocrinology, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico.)
Abstract	BACKGROUND: Recent evidence suggests that high-density lipoprotein (HDL) physicochemical characteristics and functional capacity may be more important that HDL-C levels in predicting coronary heart disease. There is little data regarding HDL subclasses distribution in youth with type 1 diabetes. OBJECTIVE: To assess the relationships between glycemic control and HDL subclasses distribution, composition, and function in adolescents with type 1 diabetes. METHODS: This cross-sectional study included 52 adolescents with type 1 diabetes aged 12-16 years and 43 age-matched non-diabetic controls. Patients were divided into two groups: one in fair control [hemoglobin A1c (HbA1c) < 9.6%] and the second group with poor glycemic control (HbA1c ≥ 9.6%). In all participants, we determined HDL subclasses distribution, composition, and the ability of plasma and of isolated HDL to promote cellular cholesterol efflux. Levels of soluble adhesion molecules were also measured. RESULTS: Although both groups of patients and the control group had similar HDL-C levels, linear regression analyses showed that compared with non-diabetic subjects, the poor control group had a lower proportion of HDL2b subclass (p = 0.029), triglyceride enriched (p = 0.045), and cholesteryl ester depleted (p = 0.028) HDL particles. Despite these HDL changes, cholesterol efflux was comparable among the three groups. The poor control group also had significantly higher intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 plasma concentrations. CONCLUSIONS: In adolescents with type 1 diabetes, poor glycemic control is associated with abnormalities in HDL subclasses distribution and HDL lipid composition, however, in spite of these HDL changes, the ability of HDL to promote cholesterol efflux remains comparable to that of healthy subjects.
File Format	HTM / HTML
ISSN	1399543X
Issue Number	6
Volume Number	14
e-ISSN	13995448
Journal	Pediatric Diabetes
Language	English
Publisher	Wiley
Publisher Date	2013-09-01
Publisher Place	Denmark
Access Restriction	Subscribed
Subject Keyword	Discipline Endocrinology Discipline Pediatrics Cholesterol, Hdl Metabolism Diabetes Mellitus, Type 1 Drug Therapy Hyperglycemia Prevention & Control Hypoglycemia Intercellular Adhesion Molecule-1 Blood Lipoproteins, Hdl Vascular Cell Adhesion Molecule-1 Adolescent Animals Biological Transport Cell Line Child Cross-sectional Studies Female Hemoglobin A, Glycosylated Analysis Hepatocytes Humans Hypoglycemic Agents Therapeutic Use Insulin Chemistry Lipoproteins, Hdl2 Male Rats Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Pediatrics, Perinatology and Child Health

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