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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Aranda, M. Albendea, C. D. Lostalé, F. López-Pingarrón, L. Fuentes-Broto, L. Martínez-Ballarín, E. Reiter, R. J. Pérez-Castejón, M. C. García, J. J. |
| Description | Country affiliation: Spain Author Affiliation: Aranda M ( Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain.) |
| Abstract | Abstract: The protective in vivo effects of melatonin or pinoline on carbon tetrachloride $(CCl_{4})-induced$ oxidative damage were investigated in liver of rats and compared to rats injected only with $CCl_{4}$ (5 mL/kg body weight). Hepatic cell membrane fluidity, monitored using fluorescence spectroscopy, exhibited a significant decrease in animals exposed to $CCl_{4}$ compared to control rats. Increases in lipid and protein oxidation, as assessed by concentrations of malondialdehyde (MDA) and 4-hydroxyalkenals (4-HDA), and protein carbonylation, respectively, were also seen in hepatic homogenates of animals exposed to $CCl_{4}.$ The administration of melatonin (10 mg/kg body weight) or pinoline injected 30 min before and 1 hr after $CCl_{4},$ fully prevented membrane rigidity and protein oxidation. However, treatment with melatonin was more effective in terms of reducing lipid peroxidation than pinoline, as the increases in MDA+4-HDA levels because of $CCl_{4}$ were reduced by 93.4% and 34.4% for melatonin or pinoline, respectively. Livers from $CCl_{4}-injected$ rats showed several histopathological alterations; above all, there were signs of necrosis and ballooning degeneration. The concurrent administration of melatonin or pinoline reduced the severity of these morphological changes. On the basis of the biochemical and histopathological findings, we conclude that both melatonin and pinoline were highly effective in protecting the liver against oxidative damage and membrane rigidity because of $CCl_{4}.$ Therefore, these indoles may be useful as cotreatments for patients with hepatic intoxication induced by $CCl_{4}.$ |
| File Format | HTM / HTML |
| ISSN | 07423098 |
| Issue Number | 1 |
| Volume Number | 49 |
| e-ISSN | 1600079X |
| Journal | Journal of Pineal Research |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2010-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology Carbolines Pharmacology Carbon Tetrachloride Poisoning Drug Therapy Carbon Tetrachloride Toxicity Drug-induced Liver Injury Liver Drug Effects Melatonin Oxidative Stress Animals Metabolism Pathology Histocytochemistry Lipid Peroxidation Male Malondialdehyde Membrane Fluidity Photomicrography Protein Carbonylation Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology |
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