NDLI: Removal torque analysis of implants in rabbit tibia after topical application of simvastatin gel.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Faraco-Schwed, Fatima Neves Mangueira, Luiz Macedo Ribeiro, Joao Vitor Albuquerque Antao, Alexsandro Da Silva Shibli, Jamil Awad
Description	Country affiliation: Brazil Author Affiliation: Faraco-Schwed FN ( 1 Paulista University (UNIP), São Paulo, SP, Brazil.)
Abstract	The aim of this study was to evaluate the effects of topical application of simvastatin gel (7.5 mg) on the removal torque of titanium implants in the rabbit tibia. A total of 32 surgeries were performed on 16 New Zealand rabbits for the placement of 2 implants in 1 tibia of each rabbit. Only 1 of the surgical defects was injected with 30 mg/mL of simvastatin gel before implant placement. The initial torque was set at 20 N.cm, and removal torque testing was performed 28 and 56 days postoperatively with a Tonishi torque wrench. Surgical defects were divided into 4 groups: group IG-28 (test, 28 days), group IG-56 (test, 56 days), group I-28 (control, 28 days), and group I-56 (control, 56 days). Removal torque values were higher in group IG-56 than in groups IG-28, I-28, and I-56 (P < .05). Groups IG-28, I-28, and I-56 showed similar values (P > .05). Removal torque force increased under the influence of simvastatin, indicating that topical administration of a 7.5-mg dose of simvastatin gel is effective in improving the torque force required to remove implants inserted in the rabbit tibia.
File Format	HTM / HTML
ISSN	01606972
Issue Number	1
Volume Number	40
e-ISSN	15481336
Journal	Journal of Oral Implantology
Language	English
Publisher	American Association of Implant Dentistry
Publisher Date	2014-02-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Dentistry Discipline General Surgery Bone Density Conservation Agents Pharmacology Dental Implants Device Removal Hydroxymethylglutaryl-coa Reductase Inhibitors Simvastatin Tibia Surgery Acid Etching, Dental Methods Administration, Topical Animals Dental Etching Dental Materials Chemistry Dental Prosthesis Design Gels Administration & Dosage Male Rabbits Surface Properties Drug Effects Time Factors Titanium Torque Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Oral Surgery

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