NDLI: Genotoxicity of endosseous implants using two cellular lineages in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Matsumoto, Mariza Filho, Hugo Nary Ferrari, Raquel Fernandes, Kristianne Renno, Ana Claudia Ribeiro, Daniel
Description	Country affiliation: Brazil Author Affiliation: Matsumoto M ( 1 Department of Oral and Maxillofacial Surgery, University of Sacred Heart, USC, SP, Brazil.)
Abstract	The genotoxic potential of corrosion eluates obtained from a single dental implant using murine fibroblasts or osteoblasts cells in vitro by the single-cell gel (comet) assay was examined. A single commercially available dental implant (Biotechnology) was eluted in a solution consisting of equal amounts of acetic acid and sodium chloride (0.1 M) for 1, 3, 7, 14, and 21 days. Murine fibroblast or osteoblast cultures were then exposed to all corrosion eluates obtained from endosseous dental implants for 30 minutes at 37°C. The results suggest that none of the eluates produced genotoxic changes in murine fibroblasts regardless of the length of exposure to the eluate. Similarly, no genotoxicity was found in osteoblasts. The results suggest that the dental implant eluates tested in this study did not induce genetic damage as depicted by the single-cell gel (comet) assay. Because DNA damage is an important event during oncogenesis, this study represents a relevant contribution to estimate the real risks to the cellular system induced by the corrosion products of a dental implant.
File Format	HTM / HTML
ISSN	01606972
Issue Number	1
Volume Number	40
e-ISSN	15481336
Journal	Journal of Oral Implantology
Language	English
Publisher	American Association of Implant Dentistry
Publisher Date	2014-02-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Dentistry Discipline General Surgery Dental Implants Dental Materials Pharmacology Fibroblasts Drug Effects Mutagens Osteoblasts Titanium 3t3 Cells Acetic Acid Chemistry Animals Cell Line Comet Assay Corrosion Dna Damage Mice Rats Sodium Chloride Temperature Time Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Oral Surgery

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