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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhou, Yi Liu, Xiu-Mei Wang, Ling Jiang, Xue-Hua |
| Description | Country affiliation: China Author Affiliation: Zhou Y ( Key Laboratory of Drug Targeting and Drug Delivery System, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China.) |
| Abstract | In this study, a simple and selective high-performance liquid chromatography method was developed and validated for the determination of nifekalant hydrochloride in canine plasma. Liquid-liquid extraction was used to separate nifekalant hydrochloride from canine plasma and the mean extraction recoveries of nifekalant hydrochloride and the internal standard were 82.31 and 94.81%, respectively. The chromatographic separation was performed on a Dikma Diamonsil column with a mobile phase consisting of acetonitrile-20mM phosphate buffer (pH 6.2; 30:70, v/v) with flow rate of 1.0 mL/min. The standard curve was linear over the concentration range of 20-10,000 ng/mL (r(2) > 0.99). The intra-batch and inter-batch accuracy for nifekalant hydrochloride at four concentrations were 93.14-100.47% and 96.12-103.77%, respectively. The relative standard deviations were less than 15%. The method was successfully applied to a pharmacokinetic study after the intravenous administration of nifekalant hydrochloride to beagle dogs. |
| File Format | HTM / HTML |
| ISSN | 00219665 |
| e-ISSN | 1945239X |
| Journal | Journal of Chromatographic Science |
| Issue Number | 9 |
| Volume Number | 51 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2013-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Analytical Chemistry Chromatography, High Pressure Liquid Pyrimidinones Blood Pharmacokinetics Animals Least-squares Analysis Liquid-liquid Extraction Chemistry Reproducibility Of Results Sensitivity And Specificity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Analytical Chemistry |
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