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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Peer, Cody J. Rao, Mahadev Spencer, Shawn D. Shahbazi, Shandiz Steeg, Patricia S. Schrump, David S. Figg, William D. |
| Description | Country affiliation: United States Author Affiliation: Peer CJ ( Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, USA.) |
| Abstract | 3-Deazaneplanocin A (DZNep) has been shown to have anti-cancer activity in numerous cancer types and its continued preclinical, and eventual clinical, drug development will require rapid and sensitive bioanalytical methods in order to quantitate this drug for pharmacokinetic analyses. The ultra HPLC with positive thermospray tandem mass spectrometric (LC-MS/MS) detection affords the most sensitive (limit of quantitation 5ng/mL) and rapid (3min run time) bioanalytical method to date for DZNep. Due to the polar nature of this drug and the internal standard (tubercidin), a hydrophilic-interaction column (HILIC) was used. The method was accurate, with less than 10% deviation from nominal values, as well as precise, where both within-day and between-day precisions were less than 15%. A liquid-liquid extraction procedure was able to recover â¼90% of drug from a small volume (50µL) of mouse plasma. This method was successfully applied to a pharmacokinetic study in mice intravenously injected with DZNep. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| e-ISSN | 1873376X |
| DOI | 10.1016/j.jchromb.2013.01.003 |
| Journal | Journal of Chromatography B |
| Volume Number | 927 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-05-15 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Discipline Analytical Chemistry Adenosine Analogs & Derivatives Chromatography, High Pressure Liquid Tandem Mass Spectrometry Blood Chemistry Isolation & Purification Pharmacokinetics Animals Drug Stability Least-squares Analysis Liquid-liquid Extraction Mice Reproducibility Of Results Sensitivity And Specificity Tubercidin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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