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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Iimura, Tadahiro Nakane, Ayako Sugiyama, Mayu Sato, Hiroki Makino, Yuji Watanabe, Takashi Takagi, Yuzo Numano, Rika Yamaguchi, Akira |
| Description | Country affiliation: Japan Author Affiliation: Iimura T ( Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, Tokyo, Japan. iimura.gcoe@tmd.ac.jp) |
| Abstract | Biological phenomena that exhibit periodic activity are often referred as biorhythms or biological clocks. Among these, circadian rhythms, cyclic patterns reflecting a 24-h cycle, are the most obvious in many physiological activities including bone growth and metabolism. In the late 1990s, several clock genes were isolated and their primary structures and functions were identified. The feedback loop model of transcriptional factors was proposed to work as a circadian core oscillator not only in the suprachiasmatic nuclei of the anterior hypothalamus, which is recognized as the mammalian central clock, but also in various peripheral tissues including cartilage and bone. Looking back to embryonic development, the fundamental architecture of skeletal patterning is regulated by ultradian clocks that are defined as biorhythms that cycle more than once every 24 h. As post-genomic approaches, transcriptome analysis by micro-array and bioimaging assays to detect luminescent and fluorescent signals have been exploited to uncover a more comprehensive set of genes and spatio-temporal regulation of the clockwork machinery in animal models. In this review paper, we provide an overview of topics related to these molecular clocks in skeletal biology and medicine, and discuss how fluorescence imaging approaches can contribute to widening our views of this realm of biomedical science. |
| File Format | HTM / HTML |
| ISSN | 09148779 |
| Issue Number | 3 |
| Volume Number | 30 |
| e-ISSN | 14355604 |
| Journal | Journal of Bone and Mineral Metabolism |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-05-01 |
| Publisher Place | Japan |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Metabolism Biological Clocks Physiology Bone And Bones Metabolism Animals Genetics Body Patterning Anatomy & Histology Embryology Genomics Homeodomain Proteins Humans Microscopy, Fluorescence Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Endocrinology, Diabetes and Metabolism Endocrinology |
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